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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2iejS48Protein farnesyltransferase subunit beta2.5.1.58

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2iejS48Protein farnesyltransferase subunit beta2.5.1.581.000
1sa4JANProtein farnesyltransferase subunit beta2.5.1.580.827
1ld7U66Protein farnesyltransferase subunit beta2.5.1.580.728
1mzcBNEProtein farnesyltransferase subunit beta2.5.1.580.727
1ld8U49Protein farnesyltransferase subunit beta2.5.1.580.699
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.668
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.661
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.580.652
2f0y3MNProtein farnesyltransferase subunit beta2.5.1.580.644
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.643
1o1s1NHProtein farnesyltransferase subunit beta2.5.1.580.639
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.632
1s63778Protein farnesyltransferase subunit beta2.5.1.580.631
3e30ED4Protein farnesyltransferase subunit beta2.5.1.580.628
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.624
3ksqZ96Protein farnesyltransferase subunit beta2.5.1.580.622
1o1t2NHProtein farnesyltransferase subunit beta2.5.1.580.620
3sfy3FYUncharacterized protein/0.619
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.615
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.615
3q7fED2Uncharacterized protein/0.604
4gtv7TRGeranylgeranyl transferase type-2 subunit beta2.5.1.600.524
3hxbBD5Geranylgeranyl transferase type-2 subunit beta2.5.1.600.492
1n4sCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.483
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.481
4tvj09LPoly [ADP-ribose] polymerase 22.4.2.300.462
1ni1HFPProtein farnesyltransferase subunit beta2.5.1.580.460
2fapRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.460
2fapRADSerine/threonine-protein kinase mTOR2.7.11.10.460
1nsgRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.459
1nsgRADSerine/threonine-protein kinase mTOR2.7.11.10.459
2vtdLKMUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.459
1ry8RUTAldo-keto reductase family 1 member C3/0.454
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.448
3zkuHCVIsopenicillin N synthase1.21.3.10.446
4dbs0HVAldo-keto reductase family 1 member C3/0.444
1ry0PG2Aldo-keto reductase family 1 member C3/0.443
1xf0ASDAldo-keto reductase family 1 member C3/0.443
2zsdCOAPantothenate kinase2.7.1.330.443
4driRAPSerine/threonine-protein kinase mTOR2.7.11.10.443
4driRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.443
3rsv3RSBeta-secretase 13.4.23.460.442
2wzySQXSoluble acetylcholine receptor/0.441
3n0hTOPDihydrofolate reductase1.5.1.30.440