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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2ibwCOAAcetyl-CoA acetyltransferase, mitochondrial2.3.1.9

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2ibwCOAAcetyl-CoA acetyltransferase, mitochondrial2.3.1.91.000
2ibuCOAAcetyl-CoA acetyltransferase, mitochondrial2.3.1.90.683
2ibyCOAAcetyl-CoA acetyltransferase, mitochondrial2.3.1.90.644
4c2jCOA3-ketoacyl-CoA thiolase, mitochondrial2.3.1.160.483
4ku5DCC3-oxoacyl-[ACP] synthase III/0.482
3vt5YI2Vitamin D3 receptor/0.478
4o9cCOAAcetyl-CoA acetyltransferase2.3.1.90.475
1culFOKAdenylate cyclase type 2/0.469
1culFOKAdenylate cyclase type 5/0.469
3w0jT08Vitamin D3 receptor/0.461
4g1d0VKVitamin D3 receptor A/0.461
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.459
1d3dBZTProthrombin3.4.21.50.457
3vt9YI4Vitamin D3 receptor/0.457
4fhi0S4Vitamin D3 receptor A/0.457
3q71AR6Poly [ADP-ribose] polymerase 142.4.2.300.455
4itfTFYVitamin D3 receptor/0.455
1galFADGlucose oxidase1.1.3.40.454
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.454
3a783EVVitamin D3 receptor/0.454
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.454
3w0aDS5Vitamin D3 receptor/0.453
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.453
2ylrNAPPhenylacetone monooxygenase1.14.13.920.451
4cf6CBDNAD(P)H dehydrogenase [quinone] 11.6.5.20.451
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.450
4q71FADBifunctional protein PutA/0.450
1e6eFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.448
2y0mACOHistone acetyltransferase KAT8/0.447
1q83TZ5Acetylcholinesterase3.1.1.70.445
2hamC33Vitamin D3 receptor/0.445
2npiATPmRNA cleavage and polyadenylation factor CLP1/0.445
2z78H86Geranylgeranyl pyrophosphate synthase/0.445
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.445
3kpkFADSulfide-quinone reductase/0.445
3nxxNDPDihydrofolate reductase1.5.1.30.445
4jjiNADAlcohol dehydrogenase class-3/0.445
1ipeNDPTropinone reductase 21.1.1.2360.444
4j6dTESCytochrome P450 monooxygenase/0.444
3bg7FADPyranose 2-oxidase/0.443
3vrvYSDVitamin D3 receptor/0.442
3w0c6DSVitamin D3 receptor/0.442
3gw9VNILanosterol 14-alpha-demethylase/0.441
3gwfFADCyclohexanone monooxygenase/0.441
3vqsJT1Genome polyprotein/0.441
4bb3KKAIsopenicillin N synthase1.21.3.10.441
3qwbNDPProbable quinone oxidoreductase1.6.5.50.440
3vt3VDXVitamin D3 receptor/0.440
3w0gW07Vitamin D3 receptor/0.440
4c77N01Phenylacetone monooxygenase1.14.13.920.440