scPDB - Distribution of Binding site Similarity values of 2hv5 entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2hv5	ZST	Aldose reductase	1.1.1.21

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
2hv5	ZST	Aldose reductase	1.1.1.21	1.000
2dv0	ZST	Aldose reductase	1.1.1.21	0.826
2fz9	ZST	Aldose reductase	1.1.1.21	0.785
2fz8	ZST	Aldose reductase	1.1.1.21	0.716
2pdx	ZST	Aldose reductase	1.1.1.21	0.708
2hvn	ZST	Aldose reductase	1.1.1.21	0.703
1t40	ID5	Aldose reductase	1.1.1.21	0.659
1z3n	3NA	Aldose reductase	1.1.1.21	0.656
3m4h	388	Aldose reductase	1.1.1.21	0.651
2pdm	ZST	Aldose reductase	1.1.1.21	0.650
2i16	LDT	Aldose reductase	1.1.1.21	0.644
3mb9	ZST	Aldose reductase	1.1.1.21	0.644
3ghu	LDT	Aldose reductase	1.1.1.21	0.638
3g5e	Q74	Aldose reductase	1.1.1.21	0.636
3m64	393	Aldose reductase	1.1.1.21	0.635
3lql	LDT	Aldose reductase	1.1.1.21	0.626
1z89	62P	Aldose reductase	1.1.1.21	0.622
3lbo	LDT	Aldose reductase	1.1.1.21	0.622
4gca	2X9	Aldose reductase	1.1.1.21	0.617
1us0	LDT	Aldose reductase	1.1.1.21	0.616
2ikj	393	Aldose reductase	1.1.1.21	0.616
2qxw	LDT	Aldose reductase	1.1.1.21	0.607
3ghr	LDT	Aldose reductase	1.1.1.21	0.604
2pdu	393	Aldose reductase	1.1.1.21	0.603
2pdh	47D	Aldose reductase	1.1.1.21	0.601
2hvo	ZST	Aldose reductase	1.1.1.21	0.588
2pdp	393	Aldose reductase	1.1.1.21	0.588
1t41	ID5	Aldose reductase	1.1.1.21	0.586
2ikh	LIT	Aldose reductase	1.1.1.21	0.584
2pdf	ZST	Aldose reductase	1.1.1.21	0.584
1iei	ZES	Aldose reductase	1.1.1.21	0.581
1pwl	BFI	Aldose reductase	1.1.1.21	0.579
3ghs	LDT	Aldose reductase	1.1.1.21	0.579
2pd5	ZST	Aldose reductase	1.1.1.21	0.577
2iki	388	Aldose reductase	1.1.1.21	0.576
2pdb	ZST	Aldose reductase	1.1.1.21	0.576
3ght	LDT	Aldose reductase	1.1.1.21	0.576
3len	ZST	Aldose reductase	1.1.1.21	0.574
3mc5	393	Aldose reductase	1.1.1.21	0.571
2pzn	393	Aldose reductase	1.1.1.21	0.570
2pdl	TOL	Aldose reductase	1.1.1.21	0.561
2i17	LDT	Aldose reductase	1.1.1.21	0.558
3t42	3T4	Aldose reductase	1.1.1.21	0.558
2pdi	ZST	Aldose reductase	1.1.1.21	0.555
3ld5	LDT	Aldose reductase	1.1.1.21	0.553
3lz5	LDT	Aldose reductase	1.1.1.21	0.552
4yu1	53N	Aldose reductase	1.1.1.21	0.550
2pdc	393	Aldose reductase	1.1.1.21	0.549
3m0i	ZST	Aldose reductase	1.1.1.21	0.546
2pdn	47D	Aldose reductase	1.1.1.21	0.539
2duz	ZST	Aldose reductase	1.1.1.21	0.533
2fzd	TOL	Aldose reductase	1.1.1.21	0.530
2dux	ZST	Aldose reductase	1.1.1.21	0.528
2pdg	47D	Aldose reductase	1.1.1.21	0.523
2pdj	393	Aldose reductase	1.1.1.21	0.523
1frb	ZST	Aldose reductase-related protein 2	/	0.513
2pdq	47D	Aldose reductase	1.1.1.21	0.501
1zua	TOL	Aldo-keto reductase family 1 member B10	1.1.1	0.492
1ah3	TOL	Aldose reductase	1.1.1.21	0.485
2pdw	FID	Aldose reductase	1.1.1.21	0.478
3g49	3G4	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.467
4jt8	1NR	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	3.5.1	0.466
4b12	C23	Glycylpeptide N-tetradecanoyltransferase	/	0.465
3fap	ARD	Peptidyl-prolyl cis-trans isomerase FKBP1A	5.2.1.8	0.464
3fap	ARD	Serine/threonine-protein kinase mTOR	2.7.11.1	0.464
1fap	RAP	Peptidyl-prolyl cis-trans isomerase FKBP1A	5.2.1.8	0.462
1fap	RAP	Serine/threonine-protein kinase mTOR	2.7.11.1	0.462
2pdy	FID	Aldose reductase	1.1.1.21	0.462
2iqd	LPA	Aldose reductase	1.1.1.21	0.461
2inz	OHP	Aldose reductase	1.1.1.21	0.460
1el3	I84	Aldose reductase	1.1.1.21	0.459
3g4k	ROL	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.458
4myq	19T	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.458
4mt9	2D6	Tankyrase-1	2.4.2.30	0.457
1h35	R01	Squalene--hopene cyclase	4.2.1.129	0.456
2agt	FID	Aldose reductase	1.1.1.21	0.456
1ry0	PG2	Aldo-keto reductase family 1 member C3	/	0.455
1xoq	ROF	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.455
1zgc	A2E	Acetylcholinesterase	3.1.1.7	0.455
4bbh	YBN	Glycylpeptide N-tetradecanoyltransferase	/	0.455
4jlm	1NN	Deoxycytidine kinase	2.7.1.74	0.455
1uho	VDN	cGMP-specific 3',5'-cyclic phosphodiesterase	/	0.454
1ut6	A8N	Acetylcholinesterase	3.1.1.7	0.454
2f2k	TGG	Aldose reductase	1.1.1.21	0.454
4li6	1XO	Tankyrase-1	2.4.2.30	0.454
3k4s	0MO	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.453
3wav	DWV	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	3.1.4.39	0.453
1pj6	FOL	Dimethylglycine oxidase	1.5.3.10	0.452
1ry8	RUT	Aldo-keto reductase family 1 member C3	/	0.452
2aou	CQA	Histamine N-methyltransferase	2.1.1.8	0.452
3g72	A6T	Renin	3.4.23.15	0.452
2aot	2PM	Histamine N-methyltransferase	2.1.1.8	0.450
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.450
4a32	2CD	Glycylpeptide N-tetradecanoyltransferase	/	0.450
4fap	ARD	Peptidyl-prolyl cis-trans isomerase FKBP1A	5.2.1.8	0.450
4fap	ARD	Serine/threonine-protein kinase mTOR	2.7.11.1	0.450
2ouu	35G	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.449
4e0u	0MV	Cyclic dipeptide N-prenyltransferase	/	0.449
2e99	B08	Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)	2.5.1.31	0.448
3jsx	CC2	NAD(P)H dehydrogenase [quinone] 1	1.6.5.2	0.448
4f1l	0RY	Poly [ADP-ribose] polymerase 14	2.4.2.30	0.448
4jsr	1NQ	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	3.5.1	0.448
2hzq	STR	Apolipoprotein D	/	0.446
2xup	TZ5	Acetylcholinesterase	3.1.1.7	0.446
3tfu	PL8	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	2.6.1.62	0.446
1i5r	HYC	Estradiol 17-beta-dehydrogenase 1	1.1.1.62	0.445
3gsi	THG	Dimethylglycine oxidase	1.5.3.10	0.445
3rj0	BLD	Protein BRASSINOSTEROID INSENSITIVE 1	2.7.10.1	0.445
4ara	C56	Acetylcholinesterase	3.1.1.7	0.445
4bj9	UHB	Tankyrase-2	2.4.2.30	0.445
1y2d	4DE	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.444
2fap	RAD	Peptidyl-prolyl cis-trans isomerase FKBP1A	5.2.1.8	0.444
2fap	RAD	Serine/threonine-protein kinase mTOR	2.7.11.1	0.444
4ey7	E20	Acetylcholinesterase	3.1.1.7	0.444
1udt	VIA	cGMP-specific 3',5'-cyclic phosphodiesterase	/	0.443
3zec	ANP	Adenosine monophosphate-protein transferase SoFic	2.7.7.n1	0.443
2e9a	B28	Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)	2.5.1.31	0.442
3itu	IBM	cGMP-dependent 3',5'-cyclic phosphodiesterase	3.1.4.17	0.442
4j7h	TRH	PCZA361.3	/	0.442
4pab	THG	Dimethylglycine dehydrogenase, mitochondrial	1.5.8.4	0.442
1zkn	IBM	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.441
2aov	C2M	Histamine N-methyltransferase	2.1.1.8	0.441
3w5e	NVW	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.441
4a95	9MT	Glycylpeptide N-tetradecanoyltransferase	/	0.441
4dbs	0HV	Aldo-keto reductase family 1 member C3	/	0.441
4u16	3C0	Muscarinic acetylcholine receptor M3	/	0.441
3ghv	GHC	Dihydrofolate reductase	1.5.1.3	0.440
4lcn	GNG	Cytidine and deoxycytidylate deaminase zinc-binding region	/	0.440
5fd8	A5A	Putative carboxypeptidase yocD	/	0.440
5d5a	CAU	Beta-2 adrenergic receptor	/	0.440