sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2hu6 | 37A | Macrophage metalloelastase | 3.4.24.65 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2hu6 | 37A | Macrophage metalloelastase | 3.4.24.65 | 1.000 | |
| 4guy | KLJ | Macrophage metalloelastase | 3.4.24.65 | 0.681 | |
| 3ljg | EEF | Macrophage metalloelastase | 3.4.24.65 | 0.676 | |
| 1utt | CP8 | Macrophage metalloelastase | 3.4.24.65 | 0.645 | |
| 2wo8 | 077 | Macrophage metalloelastase | 3.4.24.65 | 0.634 | |
| 4gql | R47 | Macrophage metalloelastase | 3.4.24.65 | 0.623 | |
| 3i7i | 518 | Collagenase 3 | 3.4.24 | 0.617 | |
| 3ts4 | EEG | Macrophage metalloelastase | 3.4.24.65 | 0.611 | |
| 3kec | 3KE | Collagenase 3 | 3.4.24 | 0.607 | |
| 3lil | EEA | Macrophage metalloelastase | 3.4.24.65 | 0.601 | |
| 1ztq | 033 | Collagenase 3 | 3.4.24 | 0.598 | |
| 2ovx | 4MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.596 | |
| 2woa | 576 | Macrophage metalloelastase | 3.4.24.65 | 0.593 | |
| 4i03 | L88 | Macrophage metalloelastase | 3.4.24.65 | 0.589 | |
| 3lik | EEG | Macrophage metalloelastase | 3.4.24.65 | 0.587 | |
| 4gr3 | R45 | Macrophage metalloelastase | 3.4.24.65 | 0.587 | |
| 4gr0 | R4B | Macrophage metalloelastase | 3.4.24.65 | 0.586 | |
| 4gr8 | R4C | Macrophage metalloelastase | 3.4.24.65 | 0.586 | |
| 2wo9 | 068 | Macrophage metalloelastase | 3.4.24.65 | 0.583 | |
| 3tsk | QEG | Macrophage metalloelastase | 3.4.24.65 | 0.574 | |
| 3kry | 3KR | Collagenase 3 | 3.4.24 | 0.573 | |
| 3i7g | 732 | Collagenase 3 | 3.4.24 | 0.569 | |
| 4a7b | 3W5 | Collagenase 3 | 3.4.24 | 0.558 | |
| 1you | PFD | Collagenase 3 | 3.4.24 | 0.556 | |
| 3kej | 3EJ | Collagenase 3 | 3.4.24 | 0.551 | |
| 1hy7 | MBS | Stromelysin-1 | 3.4.24.17 | 0.549 | |
| 2d1n | FA4 | Collagenase 3 | 3.4.24 | 0.548 | |
| 4a7b | 3W4 | Collagenase 3 | 3.4.24 | 0.546 | |
| 2ow1 | 7MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.538 | |
| 2ow0 | 6MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.535 | |
| 1b8y | IN7 | Stromelysin-1 | 3.4.24.17 | 0.534 | |
| 1g49 | 111 | Stromelysin-1 | 3.4.24.17 | 0.529 | |
| 1caq | DPS | Stromelysin-1 | 3.4.24.17 | 0.528 | |
| 1zvx | FIN | Neutrophil collagenase | 3.4.24.34 | 0.528 | |
| 2yig | 5EL | Collagenase 3 | 3.4.24 | 0.527 | |
| 1ciz | DPS | Stromelysin-1 | 3.4.24.17 | 0.526 | |
| 3o2x | 3O2 | Collagenase 3 | 3.4.24 | 0.520 | |
| 1xuc | PB3 | Collagenase 3 | 3.4.24 | 0.519 | |
| 3kek | 3EK | Collagenase 3 | 3.4.24 | 0.519 | |
| 1c8t | TR1 | Stromelysin-1 | 3.4.24.17 | 0.511 | |
| 4g9l | NGH | Stromelysin-1 | 3.4.24.17 | 0.508 | |
| 1xur | PB5 | Collagenase 3 | 3.4.24 | 0.501 | |
| 1d8f | SPI | Stromelysin-1 | 3.4.24.17 | 0.496 | |
| 1hov | I52 | 72 kDa type IV collagenase | 3.4.24.24 | 0.495 | |
| 2ovz | 5MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.493 | |
| 1g05 | BBH | Stromelysin-1 | 3.4.24.17 | 0.487 | |
| 1sln | INH | Stromelysin-1 | 3.4.24.17 | 0.480 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.476 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.475 | |
| 4h76 | 10B | Macrophage metalloelastase | 3.4.24.65 | 0.474 | |
| 1zs0 | EIN | Neutrophil collagenase | 3.4.24.34 | 0.473 | |
| 2d1o | FA4 | Stromelysin-1 | 3.4.24.17 | 0.472 | |
| 4dpe | NGH | Stromelysin-1 | 3.4.24.17 | 0.471 | |
| 1g4k | HQQ | Stromelysin-1 | 3.4.24.17 | 0.462 | |
| 4tm4 | FDA | KtzI | / | 0.462 | |
| 5dbf | NDP | Iridoid synthase | 1.3.1.99 | 0.462 | |
| 1d8m | BBH | Stromelysin-1 | 3.4.24.17 | 0.458 | |
| 2oxw | ILE_ALA_GLY | Macrophage metalloelastase | 3.4.24.65 | 0.458 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.456 | |
| 4k9o | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.455 | |
| 4h3g | 10Q | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.453 | |
| 2rjp | 886 | A disintegrin and metalloproteinase with thrombospondin motifs 4 | 3.4.24.82 | 0.453 | |
| 3vf3 | 0GS | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 4ja1 | NGH | Stromelysin-1 | 3.4.24.17 | 0.453 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 1hv5 | RXP | Stromelysin-3 | 3.4.24 | 0.449 | |
| 4ewo | 996 | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 5dbg | NAD | Iridoid synthase | 1.3.1.99 | 0.447 | |
| 3vg1 | 0GT | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4lxa | 1YS | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4d5g | FAD | Cyclohexane-1,2-dione hydrolase | 3.7.1.11 | 0.444 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.444 | |
| 4h3j | 10W | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4imp | NDP | Polyketide synthase extender modules 3-4 | / | 0.443 | |
| 2fdp | FRP | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.442 | |
| 3dv5 | BAV | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 4fco | 0U4 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4wdf | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.441 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.440 |