Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2hm9TRRDihydrofolate reductase1.5.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2hm9TRRDihydrofolate reductase1.5.1.31.000
1diuBDMDihydrofolate reductase1.5.1.30.543
1disBDMDihydrofolate reductase1.5.1.30.537
4elb34RDihydrofolate reductase/0.533
4ele31IDihydrofolate reductase/0.523
1re7FOLDihydrofolate reductase1.5.1.30.518
4elb34SDihydrofolate reductase/0.518
4elg52JDihydrofolate reductase/0.512
4cd2FOLDihydrofolate reductase1.5.1.30.509
1bzfTMQDihydrofolate reductase1.5.1.30.508
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.507
3fl9TOPDihydrofolate reductase/0.501
3fl8RARDihydrofolate reductase/0.498
1ddsMTXDihydrofolate reductase1.5.1.30.495
1tdrMTXDihydrofolate reductase1.5.1.30.493
1drbMTXDihydrofolate reductase1.5.1.30.492
1jolFFODihydrofolate reductase1.5.1.30.490
2qk8MTXDihydrofolate reductase/0.488
1ddrMTXDihydrofolate reductase1.5.1.30.487
1dhjMTXDihydrofolate reductase1.5.1.30.485
3hz5Z64Heat shock protein HSP 90-alpha/0.485
3p99LNPLanosterol 14-alpha-demethylase/0.482
1uyfPU1Heat shock protein HSP 90-alpha/0.481
3eigMTXDihydrofolate reductase1.5.1.30.481
1fvpFMANon-fluorescent flavoprotein/0.479
3drcMTXDihydrofolate reductase1.5.1.30.478
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.477
3och2MXDihydrofolate reductase1.5.1.30.477
1uzwCDHIsopenicillin N synthase1.21.3.10.475
4dfrMTXDihydrofolate reductase1.5.1.30.475
4i8vBHFCytochrome P450 1A11.14.14.10.473
1draMTXDihydrofolate reductase1.5.1.30.472
2ykiYKIHeat shock protein HSP 90-alpha/0.471
1dhfFOLDihydrofolate reductase1.5.1.30.467
1rc4DDFDihydrofolate reductase1.5.1.30.467
1rf7DHFDihydrofolate reductase1.5.1.30.466
2dhfDZFDihydrofolate reductase1.5.1.30.466
3tdaPN0Cytochrome P450 2D6/0.465
4j6cSTRCytochrome P450 monooxygenase/0.465
3zoiM2WIsopenicillin N synthase1.21.3.10.464
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.464
4nb6444Nuclear receptor ROR-gamma/0.464
2bu9HFVIsopenicillin N synthase1.21.3.10.463
2chw039Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.463
4bb3KKAIsopenicillin N synthase1.21.3.10.463
5cccDDFDihydrofolate reductase1.5.1.30.463
5k2bZMAAdenosine receptor A2a/0.463
1uydPU8Heat shock protein HSP 90-alpha/0.462
2ykcYKCHeat shock protein HSP 90-alpha/0.462
3ar4TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.462
1rf9DBRCamphor 5-monooxygenase1.14.15.10.461
3fkoFKOMitogen-activated protein kinase 14/0.460
1jomFFODihydrofolate reductase1.5.1.30.459
2jb4A14Isopenicillin N synthase1.21.3.10.459
3lfeZ84Mitogen-activated protein kinase 14/0.459
3zkyWT4Isopenicillin N synthase1.21.3.10.459
4elh53IDihydrofolate reductase/0.459
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.459
3ar7TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.458
4jbtASDCytochrome P450 monooxygenase/0.458
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.458
5dozNDPJamJ/0.458
4elf35IDihydrofolate reductase/0.457
4j6bPLOCytochrome P450 monooxygenase/0.457
4rn615UProthrombin3.4.21.50.457
1eioGCHGastrotropin/0.456
1rb3MTXDihydrofolate reductase1.5.1.30.456
3l8sBFFMitogen-activated protein kinase 14/0.456
4j6dTESCytochrome P450 monooxygenase/0.456
1pq944BOxysterols receptor LXR-beta/0.455
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.455
2ykbYKBHeat shock protein HSP 90-alpha/0.455
2ykjYKJHeat shock protein HSP 90-alpha/0.455
4a2zMYAGlycylpeptide N-tetradecanoyltransferase/0.455
4cgpMYAGlycylpeptide N-tetradecanoyltransferase/0.455
1qiqACCIsopenicillin N synthase1.21.3.10.454
2azzTCHPhospholipase A2, major isoenzyme3.1.1.40.454
2yk2YJXHeat shock protein HSP 90-alpha/0.454
3q44D50M1 family aminopeptidase3.4.110.454
4i1nFOLDihydrofolate reductase1.5.1.30.454
1hb3SCVIsopenicillin N synthase1.21.3.10.453
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.453
2iviACWIsopenicillin N synthase1.21.3.10.453
3ol5SAWCamphor 5-monooxygenase1.14.15.10.453
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.453
3qm4PN0Cytochrome P450 2D6/0.453
1oc1ASVIsopenicillin N synthase1.21.3.10.452
1q5dEPBEpothilone C/D epoxidase1.140.452
3ar6TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.452
1blzACVIsopenicillin N synthase1.21.3.10.451
1suiFRECaffeoyl-CoA O-methyltransferase2.1.1.1040.451
2y6fM9FIsopenicillin N synthase1.21.3.10.451
1e26GPBDihydrofolate reductase1.5.1.30.450
2agvTG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.450
2drcMTXDihydrofolate reductase1.5.1.30.450
4o761M3Bromodomain-containing protein 4/0.450
1dyjDDFDihydrofolate reductase1.5.1.30.449
1kceCB3Thymidylate synthase/0.449
2cig1DGDihydrofolate reductase1.5.1.30.449
2vbdV10Isopenicillin N synthase1.21.3.10.449
3lfcZ86Mitogen-activated protein kinase 14/0.449
1uy6PU3Heat shock protein HSP 90-alpha/0.448
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.448
3p6nDSOCamphor 5-monooxygenase1.14.15.10.448
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.447
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.446
2x23TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
2yjxYJXHeat shock protein HSP 90-alpha/0.446
1w06W05Isopenicillin N synthase1.21.3.10.445
3nwq2NCGag-Pol polyprotein3.4.23.160.445
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.445
4bbhNHWGlycylpeptide N-tetradecanoyltransferase/0.445
1jutLYDThymidylate synthase/0.444
1uyePU9Heat shock protein HSP 90-alpha/0.444
2d29FADAcyl-CoA dehydrogenase/0.444
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.444
3hazFADBifunctional protein PutA/0.444
3nx4NAPPutative oxidoreductase/0.444
1pkfEPDEpothilone C/D epoxidase1.140.443
2vbpVB1Isopenicillin N synthase1.21.3.10.443
3hz137DHeat shock protein HSP 90-alpha/0.443
4uymVOR14-alpha sterol demethylase Cyp51B/0.443
1fm9570Peroxisome proliferator-activated receptor gamma/0.442
1iyzNDPProbable quinone oxidoreductase/0.442
2h42VIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.442
3ar5TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.442
4fnyI3KALK tyrosine kinase receptor2.7.10.10.442
4jlj1NMDeoxycytidine kinase2.7.1.740.442
4uyf73BBromodomain-containing protein 2/0.442
1bk0ACVIsopenicillin N synthase1.21.3.10.441
1osvCHCBile acid receptor/0.441
2qg2A91Heat shock protein HSP 90-alpha/0.441
2vcmM11Isopenicillin N synthase1.21.3.10.441
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3p6pA6BCamphor 5-monooxygenase1.14.15.10.441
3t8xT8XT-cell surface glycoprotein CD1b/0.441
3uwlFOZThymidylate synthase/0.441
3v9y24LPeroxisome proliferator-activated receptor gamma/0.441
4wriOKAOkadaic acid binding protein 2-alpha/0.441
1re9DSOCamphor 5-monooxygenase1.14.15.10.440
1xdsDRAAclacinomycin 10-hydroxylase RdmB4.1.10.440
2y60M8FIsopenicillin N synthase1.21.3.10.440
2yvwEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.440
4b4w9L9Bifunctional protein FolD/0.440
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
4nh82LCHeat shock protein HSP 90-alpha/0.440
5hi6MTXDihydrofolate reductase/0.440