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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2h8xFMNXenA

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2h8xFMNXenA/1.000
3l5lFMNXenobiotic reductase/0.688
4uthFMNXenobiotic reductase/0.636
3n14FMNXenobiotic reductase/0.632
3l67FMNXenobiotic reductase/0.623
1z44FMNNADPH dehydrogenase/0.539
3hf3FMNChromate reductase/0.519
3p74FMNPentaerythritol tetranitrate reductase/0.517
4utlFNRXenobiotic reductase/0.500
1vyrFMNPentaerythritol tetranitrate reductase/0.499
3kruFMNNADH:flavin oxidoreductase/NADH oxidase/0.499
1icqFMN12-oxophytodienoate reductase 11.3.1.420.494
3q7fED2Uncharacterized protein/0.483
3n19FNRXenobiotic reductase/0.482
1icpFMN12-oxophytodienoate reductase 11.3.1.420.480
3hgsFMN12-oxophytodienoate reductase 31.3.1.420.476
3gr8FMNNADPH dehydrogenase/0.470
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.469
3hgrFMN12-oxophytodienoate reductase 11.3.1.420.469
3p62FMNPentaerythritol tetranitrate reductase/0.466
3hgoFMN12-oxophytodienoate reductase 31.3.1.420.462
1h63FMNPentaerythritol tetranitrate reductase/0.461
3p67FMNPentaerythritol tetranitrate reductase/0.461
4df2FMNNADPH dehydrogenase/0.460
3f03FMNPentaerythritol tetranitrate reductase/0.457
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.455
1mzcBNEProtein farnesyltransferase subunit beta2.5.1.580.453
3ksqZ96Protein farnesyltransferase subunit beta2.5.1.580.453
2zsaADPPantothenate kinase2.7.1.330.452
2zs9ADPPantothenate kinase2.7.1.330.450
1ld7U66Protein farnesyltransferase subunit beta2.5.1.580.449
3p8iFMNPentaerythritol tetranitrate reductase/0.449
4lutDCSAlanine racemase/0.449
4utkFNRXenobiotic reductase/0.448
2hs8FMN12-oxophytodienoate reductase 31.3.1.420.447
4rvfTYDD-mycarose 3-C-methyltransferase/0.447
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.580.446
2geuCOKPantothenate kinase2.7.1.330.446
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.446
3p84FMNPentaerythritol tetranitrate reductase/0.445
1z41FMNNADPH dehydrogenase/0.444
2gevCOKPantothenate kinase2.7.1.330.444
3e30ED4Protein farnesyltransferase subunit beta2.5.1.580.443
3p8jFMNPentaerythritol tetranitrate reductase/0.443
4acuQN7Beta-secretase 13.4.23.460.443
1q20PLOSulfotransferase family cytosolic 2B member 12.8.2.20.442
2hs6FMN12-oxophytodienoate reductase 31.3.1.420.442
3af1GDPPantothenate kinase2.7.1.330.442
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.442
4jb1NAPUDP-N-acetylenolpyruvoylglucosamine reductase/0.442
1h50FMNPentaerythritol tetranitrate reductase/0.441
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.441
1s63778Protein farnesyltransferase subunit beta2.5.1.580.441
3af0GDPPantothenate kinase2.7.1.330.441
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.441
4c13UMLUDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase/0.441
4qaiFMNNADPH dehydrogenase/0.441
1o1s1NHProtein farnesyltransferase subunit beta2.5.1.580.440
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.440
3sfy3FYUncharacterized protein/0.440
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.440
4bfzZVZPantothenate kinase2.7.1.330.440