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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2fr0NDP6-deoxyerythronolide-B synthase EryA1, modules 1 and 2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2fr0NDP6-deoxyerythronolide-B synthase EryA1, modules 1 and 2/1.000
4n5nNAPAcetoacetyl-CoA reductase1.1.1.360.515
2d29FADAcyl-CoA dehydrogenase/0.502
2fr1NDP6-deoxyerythronolide-B synthase EryA1, modules 1 and 2/0.490
4nbwNADShort-chain dehydrogenase/reductase SDR/0.486
3lqfNADGalactitol dehydrogenase/0.480
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.479
1b2lNDCAlcohol dehydrogenase1.1.1.10.478
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.476
4ipw1G7Mycocyclosin synthase1.14.21.90.476
4k6fNAPPutative Acetoacetyl-CoA reductase/0.475
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.471
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.468
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.467
4ips1G4Mycocyclosin synthase1.14.21.90.467
4dbzNDPPutative ketoacyl reductase1.3.10.466
3atzFMNProstaglandin F2a synthase/0.464
4o1mNADEnoyl-acyl carrier reductase/0.462
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.461
1jioDEB6-deoxyerythronolide B hydroxylase/0.461
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.461
4q71FADBifunctional protein PutA/0.461
1obnASVIsopenicillin N synthase1.21.3.10.459
4dc0NDPPutative ketoacyl reductase1.3.10.459
4esoNAPPutative oxidoreductase/0.459
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.457
3g5hYTTMycocyclosin synthase1.14.21.90.456
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.456
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.454
1xddAAYIntegrin alpha-L/0.453
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.451
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.451
2ok7FADFerredoxin--NADP reductase, apicoplast/0.450
2vbdV10Isopenicillin N synthase1.21.3.10.449
2yozOVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.449
3zoiM2WIsopenicillin N synthase1.21.3.10.449
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.449
1jolFFODihydrofolate reductase1.5.1.30.448
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.447
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.446
4bb3KKAIsopenicillin N synthase1.21.3.10.446
5fm7ADPRuvB-like helicase/0.446
1re7FOLDihydrofolate reductase1.5.1.30.443
3pqbVGPPutative oxidoreductase/0.443
3ruhNADUDP-N-acetylglucosamine 4-epimerase/0.443
4cd2FOLDihydrofolate reductase1.5.1.30.443
1x1aSAMC-20 methyltransferase/0.442
3ruaNADUDP-N-acetylglucosamine 4-epimerase/0.442
3t1tGDPProbable gliding protein mglA/0.442
4g3jVNTLanosterol 14-alpha-demethylase/0.442
4q73FADBifunctional protein PutA/0.442
1tdrMTXDihydrofolate reductase1.5.1.30.441
1xe65FPPlasmepsin-23.4.23.390.441
2ft9CHDFatty acid-binding protein 2, liver/0.441
3atyFMNProstaglandin F2a synthase/0.441
3eheNADUDP-glucose 4-epimerase (GalE-1)/0.441
1culFOKAdenylate cyclase type 2/0.440
1culFOKAdenylate cyclase type 5/0.440
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.440
5irnADPNucleotide binding oligomerization domain containing 2/0.440