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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2ek9BESAminopeptidase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2ek9BESAminopeptidase/1.000
1i3lNADUDP-glucose 4-epimerase/0.481
1b15NAEAlcohol dehydrogenase1.1.1.10.462
4lk3NADUDP-glucuronic acid decarboxylase 14.1.1.350.461
2p9eNAID-3-phosphoglycerate dehydrogenase1.1.1.950.460
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.459
4yagNAIC alpha-dehydrogenase/0.457
1wvgAPRCDP-glucose 4,6-dehydratase4.2.1.450.456
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.456
5a88ADPRiboflavin biosynthesis protein RibF2.7.1.260.454
1f3pFADFerredoxin reductase/0.453
1yxqSWIActin, alpha skeletal muscle/0.453
3q65NAPAldose reductase1.1.1.210.452
3s55NADPutative short-chain dehydrogenase/reductase/0.452
4gllNADUDP-glucuronic acid decarboxylase 14.1.1.350.452
4yaiNAIC alpha-dehydrogenase/0.452
2pa3NAID-3-phosphoglycerate dehydrogenase1.1.1.950.451
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.451
2aazCB3Thymidylate synthase2.1.1.450.450
2x6tNAPADP-L-glycero-D-manno-heptose-6-epimerase/0.450
3ggoNAIPrephenate dehydrogenase/0.450
1p8dCO1Oxysterols receptor LXR-beta/0.449
1g1aNADdTDP-glucose 4,6-dehydratase/0.448
5bsgNAPPyrroline-5-carboxylate reductase/0.448
1b16NAQAlcohol dehydrogenase1.1.1.10.447
2hjrAPRMalate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase/0.447
3u4cNDPNADPH-dependent reductase BacG/0.447
3ruhNADUDP-N-acetylglucosamine 4-epimerase/0.446
4dieC5PCytidylate kinase/0.445
1rkxNADCDP-D-glucose-4,6-dehydratase/0.444
1z7yAA5Cysteine synthase 12.5.1.470.444
3v0o4GWHisto-blood group ABO system transferase/0.444
1ybaNADD-3-phosphoglycerate dehydrogenase1.1.1.950.443
2jn3JN3Fatty acid-binding protein, liver/0.443
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
4lisNADUDP-glucose 4-epimerase (Eurofung)/0.443
1qiqACCIsopenicillin N synthase1.21.3.10.442
2y6fM9FIsopenicillin N synthase1.21.3.10.442
1l7eNAINAD(P) transhydrogenase subunit alpha part 11.6.1.20.441
4xybNDPFormate dehydrogenase/0.441
1dayGNPCasein kinase II subunit alpha2.7.11.10.440
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.440
1hk3T44Serum albumin/0.440
1joaFADNADH peroxidase1.11.1.10.440
1yhjR6CPyridoxal kinase2.7.1.350.440
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.440
2o7pNAPRiboflavin biosynthesis protein RibD/0.440
4egbNADdTDP-glucose 4,6-dehydratase/0.440