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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2ehuNAD1-pyrroline-5-carboxylate dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2ehuNAD1-pyrroline-5-carboxylate dehydrogenase/1.000
2j5nNAD1-pyrroline-5-carboxylate dehydrogenase/0.728
2j40NAD1-pyrroline-5-carboxylate dehydrogenase/0.708
2eiiNAD1-pyrroline-5-carboxylate dehydrogenase/0.695
2bhpNAD1-pyrroline-5-carboxylate dehydrogenase/0.651
2ehqNAP1-pyrroline-5-carboxylate dehydrogenase/0.551
4pz2NADAldehyde dehydrogenase 2-6/0.506
4v37NADBetaine aldehyde dehydrogenase, chloroplastic1.2.1.80.490
1o01NADAldehyde dehydrogenase, mitochondrial1.2.1.30.473
2bjaNAD1-pyrroline-5-carboxylate dehydrogenase/0.471
2onpNADAldehyde dehydrogenase, mitochondrial1.2.1.30.470
2eitNAD1-pyrroline-5-carboxylate dehydrogenase/0.463
1o00NADAldehyde dehydrogenase, mitochondrial1.2.1.30.458
4fqfNADAldehyde dehydrogenase, mitochondrial1.2.1.30.453
3iwkNADAminoaldehyde dehydrogenase/0.452
1o02NADAldehyde dehydrogenase, mitochondrial1.2.1.30.447
3hazNADBifunctional protein PutA/0.447
4pt0NADAldehyde dehydrogenase/0.444
1bxsNADRetinal dehydrogenase 11.2.1.360.442
1o04NADAldehyde dehydrogenase, mitochondrial1.2.1.30.442
2onmNADAldehyde dehydrogenase, mitochondrial1.2.1.30.440