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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2e4nSAHDiphthine synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2e4nSAHDiphthine synthase/1.000
2el3SAHDiphthine synthase/0.849
2huvSAHDiphthine synthase/0.828
2eldSAHDiphthine synthase/0.824
2pb6SAHDiphthine synthase/0.810
2ek4SAHDiphthine synthase/0.806
2ek2SAHDiphthine synthase/0.761
2owgSAHDiphthine synthase/0.760
2huqSAHDiphthine synthase/0.756
2e07SAHDiphthine synthase/0.753
2z6rSAHDiphthine synthase/0.742
2eh4SAHDiphthine synthase/0.741
2e8rSAHDiphthine synthase/0.737
2p9dSAHDiphthine synthase/0.733
2pcaSAHDiphthine synthase/0.729
2huxSAHDiphthine synthase/0.722
1wngSAHDiphthine synthase/0.713
2e17SAHDiphthine synthase/0.712
2el0SAHDiphthine synthase/0.712
2owkSAHDiphthine synthase/0.703
2dv3SAHDiphthine synthase/0.700
2e8qSAHDiphthine synthase/0.697
2en5SAHDiphthine synthase/0.690
2ehlSAHDiphthine synthase/0.684
2dsgSAHDiphthine synthase/0.683
2ed5SAHDiphthine synthase/0.683
2emuSAHDiphthine synthase/0.682
2eh2SAHDiphthine synthase/0.678
2pcgSAHDiphthine synthase/0.677
2pchSAHDiphthine synthase/0.676
2pb5SAHDiphthine synthase/0.674
2hutSAHDiphthine synthase/0.672
2ejjSAHDiphthine synthase/0.669
2emrSAHDiphthine synthase/0.665
2dxxSAHDiphthine synthase/0.664
1vceSAHDiphthine synthase/0.660
2e15SAHDiphthine synthase/0.659
2eleSAHDiphthine synthase/0.655
2pb4SAHDiphthine synthase/0.655
2e7rSAHDiphthine synthase/0.652
2p6lSAHDiphthine synthase/0.651
2dekSAHDiphthine synthase/0.648
2ek3SAHDiphthine synthase/0.648
2owuSAHDiphthine synthase/0.646
2dv4SAHDiphthine synthase/0.645
2dxwSAHDiphthine synthase/0.635
2ed3SAHDiphthine synthase/0.635
2eh5SAHDiphthine synthase/0.635
2p5cSAHDiphthine synthase/0.635
2eniSAHDiphthine synthase/0.634
2eeqSAHDiphthine synthase/0.631
2pckSAHDiphthine synthase/0.629
2p6iSAHDiphthine synthase/0.628
2pciSAHDiphthine synthase/0.627
2ek7SAHDiphthine synthase/0.624
2dv5SAHDiphthine synthase/0.622
2dv7SAHDiphthine synthase/0.619
2e16SAHDiphthine synthase/0.619
2ejkSAHDiphthine synthase/0.618
2hr8SAHDiphthine synthase/0.618
2dxvSAHDiphthine synthase/0.615
2dshSAHDiphthine synthase/0.614
2e8sSAHDiphthine synthase/0.611
2p5fSAHDiphthine synthase/0.608
2pcmSAHDiphthine synthase/0.605
2p6dSAHDiphthine synthase/0.601
2e08SAHDiphthine synthase/0.600
2dsiSAHDiphthine synthase/0.596
2eglSAHDiphthine synthase/0.594
2p2xSAHDiphthine synthase/0.591
2ekaSAHDiphthine synthase/0.584
2p6kSAHDiphthine synthase/0.584
2e8hSAHDiphthine synthase/0.583
2owfSAHDiphthine synthase/0.562
2owvSAHDiphthine synthase/0.553
2ejzSAHDiphthine synthase/0.549
2egbSAHDiphthine synthase/0.538
2egsSAHDiphthine synthase/0.524
1xe55FEPlasmepsin-23.4.23.390.490
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.483
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.477
1o97FADElectron transfer flavoprotein subunit alpha/0.473
1f8fNADBenzyl alcohol dehydrogenase/0.472
2ifaFMNUncharacterized protein/0.472
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.472
4bfzZVZPantothenate kinase2.7.1.330.469
2g1s4IGRenin3.4.23.150.468
2givACOHistone acetyltransferase KAT8/0.468
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.464
3gw9VNILanosterol 14-alpha-demethylase/0.464
2gjlFMNNitronate monooxygenase1.13.12.160.462
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.462
2xlrFADPutative flavin-containing monooxygenase/0.461
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.461
2xhd7T9Glutamate receptor 2/0.460
2y3sTIRTamL/0.459
3ig6438Urokinase-type plasminogen activator3.4.21.730.457
4irnFADAnaB/0.457
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.457
1lbcCYZGlutamate receptor 2/0.455
2pswCOAN-alpha-acetyltransferase 50/0.455
1g63FMNEpidermin decarboxylase4.1.10.454
1pjcNADAlanine dehydrogenase/0.454
1w6hTITPlasmepsin-23.4.23.390.454
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
4nbwNADShort-chain dehydrogenase/reductase SDR/0.454
1xl5190Gag-Pol polyprotein3.4.23.160.453
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.453
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.452
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.452
3up5FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.452
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.452
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
4wriOKAOkadaic acid binding protein 2-alpha/0.451
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.450
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.449
4a83DXCMajor pollen allergen Bet v 1-A/0.449
1xddAAYIntegrin alpha-L/0.448
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.448
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
4bfxZVXPantothenate kinase2.7.1.330.447
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
3g70A5TRenin3.4.23.150.446
1f8wFADNADH peroxidase1.11.1.10.445
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.445
1g1aNADdTDP-glucose 4,6-dehydratase/0.444
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.444
3pwm017Gag-Pol polyprotein3.4.23.160.444
5irnADPNucleotide binding oligomerization domain containing 2/0.444
1k7fIAVTryptophan synthase alpha chain/0.442
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.442
1xe65FPPlasmepsin-23.4.23.390.442
3bg7FADPyranose 2-oxidase/0.442
3d91REMRenin3.4.23.150.442
3em3478Gag-Pol polyprotein3.4.23.160.442
1dhrNADDihydropteridine reductase1.5.1.340.441
2a94AP0L-lactate dehydrogenase1.1.1.270.440
2g226IGRenin3.4.23.150.440
2he5NDPAldo-keto reductase family 1 member C211.1.10.440
2oapANPType II secretion system protein (GspE-2)/0.440
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.440
3itjFADThioredoxin reductase 11.8.1.90.440
3sf6FDAGlutaryl-CoA dehydrogenase/0.440
4g7gVFVLanosterol 14-alpha-demethylase/0.440