Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
PDB ID | HET | Uniprot Name | EC Number |
---|---|---|---|
2dgn | DOI | Adenylosuccinate synthetase isozyme 1 |
PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
---|---|---|---|---|---|
2dgn | DOI | Adenylosuccinate synthetase isozyme 1 | / | 1.000 | |
1qf5 | RPL | Adenylosuccinate synthetase | / | 0.564 | |
1qf4 | RPD | Adenylosuccinate synthetase | / | 0.548 | |
1cg0 | IMO | Adenylosuccinate synthetase | / | 0.539 | |
1lon | IMO | Adenylosuccinate synthetase isozyme 1 | / | 0.534 | |
1p9b | IMO | Adenylosuccinate synthetase | / | 0.533 | |
1cg4 | IMO | Adenylosuccinate synthetase | / | 0.526 | |
1ksz | PGS | Adenylosuccinate synthetase | / | 0.522 | |
2gcq | DOI | Adenylosuccinate synthetase | / | 0.515 | |
1cg3 | IMO | Adenylosuccinate synthetase | / | 0.503 | |
1nht | PGS | Adenylosuccinate synthetase | / | 0.493 | |
2eba | FAD | Putative glutaryl-CoA dehydrogenase | / | 0.493 | |
1cg1 | IMO | Adenylosuccinate synthetase | / | 0.492 | |
3iaa | TYD | CalG2 | / | 0.492 | |
2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.491 | |
1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.487 | |
3o0o | 5AD | Vitamin B12-dependent ribonucleotide reductase | / | 0.482 | |
4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.482 | |
1xdd | AAY | Integrin alpha-L | / | 0.481 | |
1lbc | CYZ | Glutamate receptor 2 | / | 0.478 | |
3f3s | NAD | Lambda-crystallin homolog | / | 0.478 | |
3r7k | FDA | Probable acyl CoA dehydrogenase | / | 0.477 | |
4amb | DUD | Putative glycosyl transferase | / | 0.475 | |
4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.475 | |
3uoy | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.474 | |
2c20 | NAD | UDP-glucose 4-epimerase | / | 0.472 | |
1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.471 | |
3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.470 | |
3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.470 | |
2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.469 | |
2xx9 | 1NF | Glutamate receptor 2 | / | 0.469 | |
4dd8 | BAT | Disintegrin and metalloproteinase domain-containing protein 8 | 3.4.24 | 0.469 | |
3tox | NAP | Putative oxidoreductase | / | 0.467 | |
1udy | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.466 | |
1ha3 | MAU | Elongation factor Tu-A | / | 0.465 | |
3b6z | CO7 | Enoyl reductase LovC | 1 | 0.465 | |
4eud | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.465 | |
2giv | ACO | Histone acetyltransferase KAT8 | / | 0.463 | |
2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.463 | |
3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.463 | |
3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.463 | |
3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.463 | |
4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.463 | |
5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.463 | |
2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.462 | |
3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.462 | |
4mdh | NAD | Malate dehydrogenase, cytoplasmic | 1.1.1.37 | 0.462 | |
1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.461 | |
2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.461 | |
4yag | NAI | C alpha-dehydrogenase | / | 0.461 | |
4yai | NAI | C alpha-dehydrogenase | / | 0.461 | |
2bl4 | NAD | Lactaldehyde reductase | 1.1.1.77 | 0.460 | |
3r95 | ACO | MccE protein | / | 0.460 | |
3lqs | PSZ | D-alanine aminotransferase | 2.6.1.21 | 0.459 | |
3ox4 | NAD | Alcohol dehydrogenase 2 | 1.1.1.1 | 0.459 | |
4d5g | FAD | Cyclohexane-1,2-dione hydrolase | 3.7.1.11 | 0.459 | |
4q0k | GA3 | Phytohormone-binding protein | / | 0.459 | |
5e5h | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.459 | |
5js6 | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.459 | |
1cdo | NAD | Alcohol dehydrogenase 1 | 1.1.1.1 | 0.458 | |
1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.458 | |
1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.458 | |
2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.458 | |
2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.458 | |
2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.458 | |
4h8a | NAI | Ureidoglycolate dehydrogenase (NAD(+)) | 1.1.1.350 | 0.458 | |
4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.458 | |
2iku | LIY | Renin | 3.4.23.15 | 0.457 | |
2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.457 | |
3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.457 | |
1rne | C60 | Renin | 3.4.23.15 | 0.456 | |
2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.456 | |
2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.456 | |
4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.456 | |
1szg | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.455 | |
1t9g | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.455 | |
3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.455 | |
5ahs | FAD | Acyl-CoA dehydrogenase | / | 0.455 | |
1yqx | NAP | Sinapyl alcohol dehydrogenase | / | 0.454 | |
2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.454 | |
2zfn | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.454 | |
3lqf | NAD | Galactitol dehydrogenase | / | 0.454 | |
4opi | FDA | Conserved Archaeal protein | / | 0.454 | |
4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.454 | |
2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.453 | |
2xhd | 7T9 | Glutamate receptor 2 | / | 0.453 | |
3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.453 | |
3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
3wid | NAP | Glucose 1-dehydrogenase | / | 0.453 | |
4dfg | 0JV | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
4g9k | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.453 | |
1jkx | 138 | Phosphoribosylglycinamide formyltransferase | / | 0.452 | |
1nuq | NXX | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.452 | |
1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.452 | |
1x1c | SAH | C-20 methyltransferase | / | 0.452 | |
3b70 | NAP | Enoyl reductase LovC | 1 | 0.452 | |
3dzv | ADP | Hydroxyethylthiazole kinase | / | 0.452 | |
3r96 | ACO | MccE protein | / | 0.452 | |
4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.452 | |
4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.452 | |
1ae1 | NAP | Tropinone reductase 1 | / | 0.451 | |
1het | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.451 | |
2ifa | FMN | Uncharacterized protein | / | 0.451 | |
2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.451 | |
3vyd | VYD | Renin | 3.4.23.15 | 0.451 | |
4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.451 | |
1egd | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.450 | |
2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.450 | |
2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.450 | |
3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.450 | |
4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.450 | |
5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.450 | |
1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.449 | |
1xkv | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.449 | |
2g1s | 4IG | Renin | 3.4.23.15 | 0.449 | |
2il2 | LIX | Renin | 3.4.23.15 | 0.449 | |
2qjo | NAD | Bifunctional NMN adenylyltransferase/Nudix hydrolase | 2.7.7.1 | 0.449 | |
2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
3gqv | NAP | Enoyl reductase LovC | 1 | 0.449 | |
3hl0 | NAD | Maleylacetate reductase | / | 0.449 | |
3ruh | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.449 | |
4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.449 | |
4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.449 | |
4iv6 | FDA | Isovaleryl-CoA dehydrogenase | / | 0.449 | |
4ji9 | 1M3 | Tyrosine-protein kinase JAK2 | / | 0.449 | |
4tlz | FAD | KtzI | / | 0.449 | |
4ytn | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.449 | |
5af7 | FAD | Acyl-CoA dehydrogenase | / | 0.449 | |
5fm7 | ADP | RuvB-like helicase | / | 0.449 | |
5jyd | NAD | Short chain dehydrogenase | / | 0.449 | |
1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.448 | |
1mja | COA | Histone acetyltransferase ESA1 | / | 0.448 | |
1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.448 | |
1ykf | NAP | NADP-dependent isopropanol dehydrogenase | 1.1.1.80 | 0.448 | |
2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.448 | |
2p5u | NAD | UDP-glucose 4-epimerase | / | 0.448 | |
3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.448 | |
3qfr | FMN | NADPH--cytochrome P450 reductase | / | 0.448 | |
4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.448 | |
4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.448 | |
5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.448 | |
1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.447 | |
1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.447 | |
1w4x | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.447 | |
1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.447 | |
2e07 | SAH | Diphthine synthase | / | 0.447 | |
2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.447 | |
2gh5 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.447 | |
2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.447 | |
2qn3 | F55 | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.447 | |
4eu5 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.447 | |
4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.447 | |
4xd2 | NAI | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.447 | |
1bim | 0QB | Renin | 3.4.23.15 | 0.446 | |
1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.446 | |
1zem | NAD | Xylitol dehydrogenase | / | 0.446 | |
2g1y | 5IG | Renin | 3.4.23.15 | 0.446 | |
3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.446 | |
3d91 | REM | Renin | 3.4.23.15 | 0.446 | |
3lu1 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.446 | |
3nl6 | TPS | Uncharacterized protein | / | 0.446 | |
3uax | NOS | Purine nucleoside phosphorylase DeoD-type | / | 0.446 | |
3wag | TYD | Glycosyltransferase | / | 0.446 | |
4lcj | NAD | C-terminal-binding protein 2 | / | 0.446 | |
4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.446 | |
2irz | I02 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
2npi | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.445 | |
4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
4kuh | CAA | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.445 | |
1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.444 | |
1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
1jue | FMN | Dihydroorotate dehydrogenase A (fumarate) | 1.3.98.1 | 0.444 | |
1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.444 | |
2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.444 | |
2g1r | 3IG | Renin | 3.4.23.15 | 0.444 | |
2xtn | GTP | GTPase IMAP family member 2 | / | 0.444 | |
3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.444 | |
3mau | EXT | Putative sphingosine-1-phosphate lyase | / | 0.444 | |
3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
3zid | GDP | Tubulin-like protein CetZ | / | 0.444 | |
4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.444 | |
5c2t | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.444 | |
5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.444 | |
1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.443 | |
1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
2fon | FAD | Acyl-coenzyme A oxidase | / | 0.443 | |
2gvd | FKP | Adenylate cyclase type 2 | / | 0.443 | |
2gvd | FKP | Adenylate cyclase type 5 | / | 0.443 | |
2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.443 | |
3jv7 | NAD | Secondary alcohol dehydrogenase | / | 0.443 | |
3sxp | NAD | ADP-L-glycero-D-mannoheptose-6-epimerase | / | 0.443 | |
3tjz | GNP | ADP-ribosylation factor 1 | / | 0.443 | |
4an4 | DUD | Putative glycosyl transferase | / | 0.443 | |
4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.443 | |
5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.443 | |
1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.442 | |
1p0f | NAP | NADP-dependent alcohol dehydrogenase | 1.1.1.2 | 0.442 | |
2a92 | NAI | L-lactate dehydrogenase | / | 0.442 | |
2e8r | SAH | Diphthine synthase | / | 0.442 | |
2qbu | SAH | Precorrin-2 methyltransferase | / | 0.442 | |
2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.442 | |
2x0i | NAI | Malate dehydrogenase | / | 0.442 | |
3kgc | LY7 | Glutamate receptor 2 | / | 0.442 | |
3ru7 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.442 | |
3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
4blr | UTP | NTPase P4 | / | 0.442 | |
4eua | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.442 | |
4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.442 | |
4ozt | P1A | Ecdysone receptor, putative | / | 0.442 | |
4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.442 | |
5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.442 | |
1ege | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.441 | |
1g8j | MGD | Arsenite oxidase subunit AioA | 1.20.9.1 | 0.441 | |
1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.441 | |
1jqi | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | / | 0.441 | |
1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.441 | |
2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.441 | |
2g1o | 2IG | Renin | 3.4.23.15 | 0.441 | |
2owu | SAH | Diphthine synthase | / | 0.441 | |
2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.441 | |
3ai3 | NDP | NADPH-sorbose reductase | / | 0.441 | |
3ieu | GDP | GTPase Era | / | 0.441 | |
4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.441 | |
4gl4 | NAI | Alcohol dehydrogenase class-3 | / | 0.441 | |
4lnb | ED5 | CaaX farnesyltransferase beta subunit Ram1 | / | 0.441 | |
4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.441 | |
1bil | 0IU | Renin | 3.4.23.15 | 0.440 | |
1f0x | FAD | D-lactate dehydrogenase | 1.1.1.28 | 0.440 | |
1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.440 | |
1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.440 | |
1x1a | SAM | C-20 methyltransferase | / | 0.440 | |
2g22 | 6IG | Renin | 3.4.23.15 | 0.440 | |
2ome | NAD | C-terminal-binding protein 2 | / | 0.440 | |
3cb2 | GDP | Tubulin gamma-1 chain | / | 0.440 | |
3daa | PDD | D-alanine aminotransferase | 2.6.1.21 | 0.440 | |
3owa | FAD | Acyl-CoA dehydrogenase | / | 0.440 | |
3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.440 | |
5ao1 | DG3 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.440 |