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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2cciATPCyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2cciATPCyclin-dependent kinase 22.7.11.221.000
4eooATPCyclin-dependent kinase 22.7.11.220.517
1qmzATPCyclin-dependent kinase 22.7.11.220.485
4ii5ADPCyclin-dependent kinase 22.7.11.220.480
4fv6E57Mitogen-activated protein kinase 12.7.11.240.474
4qnyANPMitogen activated protein kinase, putative/0.469
2cjmATPCyclin-dependent kinase 22.7.11.220.466
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.462
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.460
3juhANPCasein kinase II subunit alpha2.7.11.10.458
3gu7ADPDeath-associated protein kinase 12.7.11.10.457
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
3ncz3NCRho-associated protein kinase 12.7.11.10.452
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
3i60E86Mitogen-activated protein kinase 12.7.11.240.444
4btjADPTau-tubulin kinase 12.7.11.10.442
4deeADPAurora kinase A2.7.11.10.442