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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2c6eHPMAurora kinase A2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2c6eHPMAurora kinase A2.7.11.11.000
4jbpYPHAurora kinase A2.7.11.10.477
4nka2K7Fibroblast growth factor receptor 1/0.471
4jboWPHAurora kinase A2.7.11.10.467
4eym0RXMitogen-activated protein kinase 132.7.11.240.464
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.463
2vrx447Aurora kinase B-A2.7.11.10.462
4c3pACPAurora kinase A2.7.11.10.462
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.461
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.458
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.457
4aotGW8Serine/threonine-protein kinase 102.7.11.10.456
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.455
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.453
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.448
4id71G0Activated CDC42 kinase 1/0.446