sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2anm | CDO | Prothrombin | 3.4.21.5 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2anm | CDO | Prothrombin | 3.4.21.5 | 1.000 | |
| 2v3o | I26 | Prothrombin | 3.4.21.5 | 0.693 | |
| 2r2m | I50 | Prothrombin | 3.4.21.5 | 0.690 | |
| 4ax9 | N5N | Prothrombin | 3.4.21.5 | 0.690 | |
| 1d4p | BPP | Prothrombin | 3.4.21.5 | 0.684 | |
| 1vzq | SHY | Prothrombin | 3.4.21.5 | 0.681 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.680 | |
| 1ype | UIP | Prothrombin | 3.4.21.5 | 0.679 | |
| 1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.671 | |
| 2zfr | 46U | Prothrombin | 3.4.21.5 | 0.669 | |
| 1ypm | RA4 | Prothrombin | 3.4.21.5 | 0.663 | |
| 4ayy | 9MX | Prothrombin | 3.4.21.5 | 0.657 | |
| 1c4u | IH1 | Prothrombin | 3.4.21.5 | 0.652 | |
| 2zfq | 45U | Prothrombin | 3.4.21.5 | 0.648 | |
| 1ypj | UIB | Prothrombin | 3.4.21.5 | 0.644 | |
| 2zfp | 19U | Prothrombin | 3.4.21.5 | 0.642 | |
| 2zda | 32U | Prothrombin | 3.4.21.5 | 0.641 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.640 | |
| 2bdy | UNB | Prothrombin | 3.4.21.5 | 0.635 | |
| 1ypg | UIR | Prothrombin | 3.4.21.5 | 0.634 | |
| 2zhe | 13U | Prothrombin | 3.4.21.5 | 0.633 | |
| 2jh5 | 895 | Prothrombin | 3.4.21.5 | 0.632 | |
| 2cf8 | ESH | Prothrombin | 3.4.21.5 | 0.631 | |
| 2zi2 | 24U | Prothrombin | 3.4.21.5 | 0.631 | |
| 2zgx | 29U | Prothrombin | 3.4.21.5 | 0.630 | |
| 2uuk | 897 | Prothrombin | 3.4.21.5 | 0.628 | |
| 1d9i | 00P | Prothrombin | 3.4.21.5 | 0.627 | |
| 1xm1 | GAH | Prothrombin | 3.4.21.5 | 0.627 | |
| 2zhq | 27U | Prothrombin | 3.4.21.5 | 0.626 | |
| 2zhf | 49U | Prothrombin | 3.4.21.5 | 0.623 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.619 | |
| 3hat | GLY_VAL_ARG_RNG | Prothrombin | 3.4.21.5 | 0.618 | |
| 2jh6 | 894 | Prothrombin | 3.4.21.5 | 0.613 | |
| 1zgv | 501 | Prothrombin | 3.4.21.5 | 0.611 | |
| 1t4v | 14A | Prothrombin | 3.4.21.5 | 0.607 | |
| 2cf9 | 348 | Prothrombin | 3.4.21.5 | 0.606 | |
| 3qwc | 98P | Prothrombin | 3.4.21.5 | 0.606 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.606 | |
| 1ypl | RA8 | Prothrombin | 3.4.21.5 | 0.604 | |
| 2gde | SN3 | Prothrombin | 3.4.21.5 | 0.604 | |
| 1k22 | MEL | Prothrombin | 3.4.21.5 | 0.602 | |
| 1ta6 | 177 | Prothrombin | 3.4.21.5 | 0.600 | |
| 2zhw | 12U | Prothrombin | 3.4.21.5 | 0.600 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.597 | |
| 2pks | G44 | Prothrombin | 3.4.21.5 | 0.596 | |
| 1c4y | IH3 | Prothrombin | 3.4.21.5 | 0.595 | |
| 2jh0 | 701 | Prothrombin | 3.4.21.5 | 0.595 | |
| 2zdv | 37U | Prothrombin | 3.4.21.5 | 0.595 | |
| 1z71 | L17 | Prothrombin | 3.4.21.5 | 0.594 | |
| 3eq0 | 2TS | Prothrombin | 3.4.21.5 | 0.593 | |
| 2zgb | 21U | Prothrombin | 3.4.21.5 | 0.592 | |
| 3biu | 10U | Prothrombin | 3.4.21.5 | 0.591 | |
| 2znk | 31U | Prothrombin | 3.4.21.5 | 0.590 | |
| 1mu6 | CDA | Prothrombin | 3.4.21.5 | 0.589 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.588 | |
| 4lxb | 7R9 | Prothrombin | 3.4.21.5 | 0.588 | |
| 1mue | CDD | Prothrombin | 3.4.21.5 | 0.587 | |
| 4bah | MEL | Prothrombin | 3.4.21.5 | 0.587 | |
| 3dux | 64U | Prothrombin | 3.4.21.5 | 0.585 | |
| 2bvs | 2CE | Prothrombin | 3.4.21.5 | 0.584 | |
| 2zf0 | 51U | Prothrombin | 3.4.21.5 | 0.582 | |
| 1t4u | 81A | Prothrombin | 3.4.21.5 | 0.580 | |
| 1zrb | 062 | Prothrombin | 3.4.21.5 | 0.580 | |
| 1sb1 | 165 | Prothrombin | 3.4.21.5 | 0.579 | |
| 2zc9 | 22U | Prothrombin | 3.4.21.5 | 0.579 | |
| 2zg0 | 50U | Prothrombin | 3.4.21.5 | 0.579 | |
| 1oyt | FSN | Prothrombin | 3.4.21.5 | 0.577 | |
| 4bam | MM9 | Prothrombin | 3.4.21.5 | 0.576 | |
| 1ae8 | AZL | Prothrombin | 3.4.21.5 | 0.575 | |
| 1afe | ALZ | Prothrombin | 3.4.21.5 | 0.575 | |
| 2cn0 | F25 | Prothrombin | 3.4.21.5 | 0.574 | |
| 2zff | 53U | Prothrombin | 3.4.21.5 | 0.571 | |
| 2v3h | I25 | Prothrombin | 3.4.21.5 | 0.566 | |
| 7kme | ACE_0BN_CHG_PRR | Prothrombin | 3.4.21.5 | 0.563 | |
| 1k21 | IGN | Prothrombin | 3.4.21.5 | 0.562 | |
| 1nzq | 162 | Prothrombin | 3.4.21.5 | 0.562 | |
| 3p17 | 99P | Prothrombin | 3.4.21.5 | 0.561 | |
| 1ypk | CCR | Prothrombin | 3.4.21.5 | 0.558 | |
| 4az2 | 9MU | Prothrombin | 3.4.21.5 | 0.555 | |
| 4bak | M67 | Prothrombin | 3.4.21.5 | 0.554 | |
| 1zgi | 382 | Prothrombin | 3.4.21.5 | 0.552 | |
| 4e7r | 0NW | Prothrombin | 3.4.21.5 | 0.547 | |
| 5cmx | 0G6 | Prothrombin | 3.4.21.5 | 0.544 | |
| 4bao | MVF | Prothrombin | 3.4.21.5 | 0.542 | |
| 3utu | 1TS | Prothrombin | 3.4.21.5 | 0.533 | |
| 1a4w | QWE | Prothrombin | 3.4.21.5 | 0.531 | |
| 4ban | M6S | Prothrombin | 3.4.21.5 | 0.530 | |
| 3qto | 10P | Prothrombin | 3.4.21.5 | 0.528 | |
| 4ayv | 9MQ | Prothrombin | 3.4.21.5 | 0.526 | |
| 1c4v | IH2 | Prothrombin | 3.4.21.5 | 0.525 | |
| 1riw | OSC | Prothrombin | 3.4.21.5 | 0.522 | |
| 4baq | M4Z | Prothrombin | 3.4.21.5 | 0.517 | |
| 3c27 | DKK | Prothrombin | 3.4.21.5 | 0.513 | |
| 3qtv | 06P | Prothrombin | 3.4.21.5 | 0.505 | |
| 2uuj | 896 | Prothrombin | 3.4.21.5 | 0.503 | |
| 1w7g | MIU | Prothrombin | 3.4.21.5 | 0.500 | |
| 3qdz | PRO_ALA_PRO_ARG | Prothrombin | 3.4.21.5 | 0.496 | |
| 2bxt | C2D | Prothrombin | 3.4.21.5 | 0.495 | |
| 3dhk | 23U | Prothrombin | 3.4.21.5 | 0.491 | |
| 3biv | 11U | Prothrombin | 3.4.21.5 | 0.480 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.475 | |
| 2ziq | 26U | Prothrombin | 3.4.21.5 | 0.465 | |
| 3egk | M18 | Prothrombin | 3.4.21.5 | 0.464 | |
| 1ghv | 120 | Prothrombin | 3.4.21.5 | 0.463 | |
| 1mu8 | CDB | Prothrombin | 3.4.21.5 | 0.463 | |
| 1o0d | 163 | Prothrombin | 3.4.21.5 | 0.462 | |
| 1uvs | I11 | Prothrombin | 3.4.21.5 | 0.461 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.457 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.455 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.449 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.449 | |
| 3ens | ENS | Coagulation factor X | 3.4.21.6 | 0.448 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.448 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.447 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.446 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.446 | |
| 1kts | C24 | Prothrombin | 3.4.21.5 | 0.445 | |
| 2a2x | NA9 | Prothrombin | 3.4.21.5 | 0.443 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
| 3r95 | ACO | MccE protein | / | 0.442 | |
| 5eb5 | FAD | (R)-mandelonitrile lyase 1 | 4.1.2.10 | 0.442 |