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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1yinCM3Estrogen receptor

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1yinCM3Estrogen receptor/1.000
1sj0E4DEstrogen receptor/0.642
1xp6AIUEstrogen receptor/0.620
1errRALEstrogen receptor/0.589
1uomPTIEstrogen receptor/0.582
2jf9OHTEstrogen receptor/0.542
1xqcAEJEstrogen receptor/0.531
1yimCM4Estrogen receptor/0.506
2gpvOHTEstrogen-related receptor gamma/0.503
2qe4JJ3Estrogen receptor/0.502
2fszOHTEstrogen receptor beta/0.496
2bj4OHTEstrogen receptor/0.492
2jfaRALEstrogen receptor/0.492
1qknRALEstrogen receptor beta/0.490
1ndeMONEstrogen receptor beta/0.481
2pogWSTEstrogen receptor/0.468
4ivw1GJEstrogen receptor/0.465
2p7zOHTEstrogen-related receptor gamma/0.459
4q73FADBifunctional protein PutA/0.457
2ewpTXFEstrogen-related receptor gamma/0.455
3abaFLICytochrome P450/0.446
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.442