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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1xkqNDPUncharacterized protein

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1xkqNDPUncharacterized protein/1.000
1xg5NAPDehydrogenase/reductase SDR family member 11/0.544
3l77NJPShort-chain alcohol dehydrogenase/0.542
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.514
4qecNAPElxO/0.505
3tn7NJPShort-chain alcohol dehydrogenase/0.498
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.493
2yutNAPPutative short-chain oxidoreductase/0.491
4pvdNDPNADPH-dependent methylglyoxal reductase GRE2/0.486
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.479
4qedNAPElxO/0.479
4bmvNAPShort-chain dehydrogenase/0.476
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.474
3ai2NDPNADPH-sorbose reductase/0.472
4j7uNAPSepiapterin reductase1.1.1.1530.472
4j7xNAPSepiapterin reductase1.1.1.1530.471
3p19NDPPutative blue fluorescent protein/0.469
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.467
1ae1NAPTropinone reductase 1/0.466
4dc1NDPPutative ketoacyl reductase1.3.10.465
3ai3NDPNADPH-sorbose reductase/0.462
3toxNAPPutative oxidoreductase/0.461
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.460
4hwkNAPSepiapterin reductase1.1.1.1530.459
2jahNDPClavaldehyde dehydrogenase/0.458
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.457
1x7hNDPPutative ketoacyl reductase1.3.10.456
3qrwNDPPutative ketoacyl reductase1.3.10.455
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.453
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.453
1snyNAPLD36273p/0.451
1w4zNAPPutative ketoacyl reductase1.3.10.451
3gy0NAPNAD(P)-dependent oxidoreductase/0.451
3lqfNADGalactitol dehydrogenase/0.451
3uceNDPDehydrogenase/0.451
1n5dNDPCarbonyl reductase [NADPH] 1/0.444
1oaaNAPSepiapterin reductase1.1.1.1530.444
5idwNAPShort-chain dehydrogenase/reductase SDR/0.444
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.442
1x7gNAPPutative ketoacyl reductase1.3.10.441