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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1upw444Oxysterols receptor LXR-beta

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1upw444Oxysterols receptor LXR-beta/1.000
1pqc444Oxysterols receptor LXR-beta/0.580
1pq6965Oxysterols receptor LXR-beta/0.579
1pq944BOxysterols receptor LXR-beta/0.567
1p8dCO1Oxysterols receptor LXR-beta/0.533
2aclL05Oxysterols receptor LXR-alpha/0.526
3ipq965Oxysterols receptor LXR-alpha/0.516
4dk70KSOxysterols receptor LXR-beta/0.506
3aosJH2Hemolymph juvenile hormone binding protein/0.484
3emlZMAAdenosine receptor A2a/0.482
1blzACVIsopenicillin N synthase1.21.3.10.479
1fmlRTLRetinol dehydratase/0.477
1dhfFOLDihydrofolate reductase1.5.1.30.469
1qiqACCIsopenicillin N synthase1.21.3.10.469
3zkyWT4Isopenicillin N synthase1.21.3.10.469
4h9506UDihydrofolate reductase1.5.1.30.469
1bk0ACVIsopenicillin N synthase1.21.3.10.466
1uzwCDHIsopenicillin N synthase1.21.3.10.464
2bu9HFVIsopenicillin N synthase1.21.3.10.464
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
5dozNDPJamJ/0.460
3a1l2CCCytochrome P450/0.459
1x8lOXRRetinol dehydratase/0.458
4phlPILPhosphodiesterase/0.458
5k2cZMAAdenosine receptor A2a/0.458
1z6tADPApoptotic protease-activating factor 1/0.457
5iubCLRAdenosine receptor A2a/0.457
2vcmM11Isopenicillin N synthase1.21.3.10.456
1w06W05Isopenicillin N synthase1.21.3.10.455
4nieNBHNuclear receptor ROR-gamma/0.455
1zidZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
1oc1ASVIsopenicillin N synthase1.21.3.10.453
3l0lHC3Nuclear receptor ROR-gamma/0.453
5k2bZMAAdenosine receptor A2a/0.453
2jb4A14Isopenicillin N synthase1.21.3.10.452
2y6fM9FIsopenicillin N synthase1.21.3.10.452
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.451
1yc2NADNAD-dependent protein deacylase 2/0.451
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.451
1hb3SCVIsopenicillin N synthase1.21.3.10.450
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.450
2hamC33Vitamin D3 receptor/0.449
2wo7ASVIsopenicillin N synthase1.21.3.10.449
4jlj1NMDeoxycytidine kinase2.7.1.740.449
4jbtASDCytochrome P450 monooxygenase/0.448
1hb1OCVIsopenicillin N synthase1.21.3.10.447
4j6cSTRCytochrome P450 monooxygenase/0.447
2iviACWIsopenicillin N synthase1.21.3.10.446
3vi7CBDHematopoietic prostaglandin D synthase/0.446
4g1z0VPVitamin D3 receptor A/0.446
3h6k33TCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
3nxvD2FDihydrofolate reductase1.5.1.30.445
3p6pA6BCamphor 5-monooxygenase1.14.15.10.445
3zoiM2WIsopenicillin N synthase1.21.3.10.445
4g1d0VKVitamin D3 receptor A/0.445
1obnASVIsopenicillin N synthase1.21.3.10.444
2vbpVB1Isopenicillin N synthase1.21.3.10.444
2z7gEH9Adenosine deaminase3.5.4.40.444
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.443
2f3815MAldo-keto reductase family 1 member C3/0.443
2hb8MVDVitamin D3 receptor/0.443
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.443
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.443
3w0iO11Vitamin D3 receptor/0.443
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.443
4eiyZMAAdenosine receptor A2a/0.443
4h9753SDihydrofolate reductase1.5.1.30.443
1v35NAIEnoyl-ACP reductase/0.442
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
2vbdV10Isopenicillin N synthase1.21.3.10.442
3fznD7KBenzoylformate decarboxylase4.1.1.70.442
3kpzZNEVitamin D3 receptor/0.442
3oafOAGDihydrofolate reductase1.5.1.30.442
3qls55VDihydrofolate reductase1.5.1.30.442
5iu4ZMAAdenosine receptor A2a/0.442
1qjfACSIsopenicillin N synthase1.21.3.10.441
1s19MC9Vitamin D3 receptor/0.441
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
3adaNADSubunit alpha of sarocosine oxidase/0.441
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
3tdaPN0Cytochrome P450 2D6/0.441
4h9614QDihydrofolate reductase1.5.1.30.441
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
2po7CHDFerrochelatase, mitochondrial4.99.1.10.440
3oquA8SAbscisic acid receptor PYL9/0.440
4jqh1MFAlr2278 protein/0.440