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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/1.000
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.585
2h42VIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.549
4oex5EOcGMP-specific 3',5'-cyclic phosphodiesterase/0.463
2h447CAcGMP-specific 3',5'-cyclic phosphodiesterase/0.461
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.459
4g2wNI0cGMP-specific 3',5'-cyclic phosphodiesterase/0.457
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
3g4lROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
3v94WYQPhosphodiesterase/0.449
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.444
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
4fcd0T6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442