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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1tsxUMPThymidylate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1tsxUMPThymidylate synthase/1.000
1bpjUMPThymidylate synthase/0.657
2g86UMPThymidylate synthase/0.654
1vzbUMPThymidylate synthase/0.636
1tsyUMPThymidylate synthase/0.608
2g8aUMPThymidylate synthase/0.605
2tdmUMPThymidylate synthase/0.598
1bp6UMPThymidylate synthase/0.570
1vzaUMPThymidylate synthase/0.566
1tsvUMPThymidylate synthase/0.558
1njdUMPThymidylate synthase/0.556
1lcbTMPThymidylate synthase/0.543
1jmiUMPThymidylate synthase/0.542
1njaDCMThymidylate synthase/0.533
2g89UMPThymidylate synthase/0.532
1jmgUMPThymidylate synthase/0.531
1jmfUMPThymidylate synthase/0.524
2vetUMPThymidylate synthase/0.504
3bgxTMPThymidylate synthase/0.504
1jmhUMPThymidylate synthase/0.492
1bidUMPThymidylate synthase/0.487
1njeDCMThymidylate synthase/0.486
1njbUMPThymidylate synthase/0.481
1aobDDUThymidylate synthase/0.479
1thyUMPThymidylate synthase/0.468
1njcDCMThymidylate synthase/0.461
3dg8UMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.456
1bp0UMPThymidylate synthase/0.455
1bduDURThymidylate synthase/0.454
4einNOHThymidylate synthase2.1.1.450.454
4dq1UMPThymidylate synthase/0.451
3dgaUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.446