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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1tilATPAnti-sigma F factor

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1tilATPAnti-sigma F factor/1.000
1thnADPAnti-sigma F factor/0.564
1l0oADPAnti-sigma F factor/0.557
3d2rADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.513
2zkjADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.509
1gjvAGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial2.7.11.40.499
1i59ANPChemotaxis protein CheA2.7.13.30.491
2ejzSAHDiphthine synthase/0.489
2e0aANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.480
4q0kGA3Phytohormone-binding protein/0.471
2ifaFMNUncharacterized protein/0.468
3dgeADPSensor histidine kinase/0.466
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.463
2p6kSAHDiphthine synthase/0.461
2xlrFADPutative flavin-containing monooxygenase/0.460
2zdyADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.460
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.459
2eleSAHDiphthine synthase/0.457
4biwANPSensor histidine kinase CpxA/0.457
4wudANPDNA gyrase subunit B/0.457
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.456
1nhhANPDNA mismatch repair protein MutL/0.454
2po7CHDFerrochelatase, mitochondrial4.99.1.10.453
2abbFMNPentaerythritol tetranitrate reductase/0.451
1z5cADPType 2 DNA topoisomerase 6 subunit B/0.450
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
1i5cADPChemotaxis protein CheA2.7.13.30.449
2c20NADUDP-glucose 4-epimerase/0.449
3h3r14HCollagen type IV alpha-3-binding protein/0.448
5dp2NAPCurF/0.448
1cqp803Integrin alpha-L/0.447
2a2cADPN-acetylgalactosamine kinase2.7.1.1570.447
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.446
2pcgSAHDiphthine synthase/0.446
4m2bUPGUDP-glucose pyrophosphorylase/0.444
1xddAAYIntegrin alpha-L/0.443
1xdsDRAAclacinomycin 10-hydroxylase RdmB4.1.10.443
2oegUPGUDP-glucose pyrophosphorylase/0.443
2p5fSAHDiphthine synthase/0.443
1fmlRTLRetinol dehydratase/0.442
2dxwSAHDiphthine synthase/0.442
2owfSAHDiphthine synthase/0.442
2p5cSAHDiphthine synthase/0.442
2p6dSAHDiphthine synthase/0.442
3b9oFMNAlkane monoxygenase/0.442
2zsaADPPantothenate kinase2.7.1.330.441
1fmjRTLRetinol dehydratase/0.440
1oc1ASVIsopenicillin N synthase1.21.3.10.440
1vceSAHDiphthine synthase/0.440
2gv8NDPThiol-specific monooxygenase1.14.130.440