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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1sj0E4DEstrogen receptor

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1sj0E4DEstrogen receptor/1.000
1xp6AIUEstrogen receptor/0.669
1yinCM3Estrogen receptor/0.635
1uomPTIEstrogen receptor/0.560
1errRALEstrogen receptor/0.553
2jf9OHTEstrogen receptor/0.528
1xqcAEJEstrogen receptor/0.515
2gpvOHTEstrogen-related receptor gamma/0.484
2ewpTXFEstrogen-related receptor gamma/0.468
2qe4JJ3Estrogen receptor/0.468
2p7zOHTEstrogen-related receptor gamma/0.459
2gpuOHTEstrogen-related receptor gamma/0.445
4iarERM5-hydroxytryptamine receptor 1B/0.445
2bj4OHTEstrogen receptor/0.444
2jfaRALEstrogen receptor/0.443
3n61XFJNitric oxide synthase, brain1.14.13.390.441