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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1rt2TNKGag-Pol polyprotein2.7.7.49

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1rt2TNKGag-Pol polyprotein2.7.7.491.000
1jlaTNKGag-Pol polyprotein2.7.7.490.663
3ffi3OBGag-Pol polyprotein2.7.7.490.610
3dleGFAGag-Pol polyprotein2.7.7.490.595
4i7fNVEGag-Pol polyprotein2.7.7.490.592
3i0rRT3Gag-Pol polyprotein2.7.7.490.585
3i0sRT7Gag-Pol polyprotein2.7.7.490.583
3dmjGWEPol protein/0.578
3is9AC7Gag-Pol polyprotein2.7.7.490.578
3lanKBTGag-Pol polyprotein2.7.7.490.572
3dolGWIPol protein/0.558
3lamKRPGag-Pol polyprotein2.7.7.490.555
1c1bGCAGag-Pol polyprotein2.7.7.490.554
1rtiHEFGag-Pol polyprotein2.7.7.490.552
3dlgGWEGag-Pol polyprotein2.7.7.490.552
1rt1MKCGag-Pol polyprotein2.7.7.490.550
3nbpJGZGag-Pol polyprotein2.7.7.490.547
3c6uM22Gag-Pol polyprotein2.7.7.490.542
1tvrTB9Gag-Pol polyprotein2.7.7.490.540
3drrR8EGag-Pol polyprotein2.7.7.490.538
1klmSPPGag-Pol polyprotein2.7.7.490.537
3dokGWJPol protein/0.537
1tl3H20Gag-Pol polyprotein2.7.7.490.535
3irxUDRGag-Pol polyprotein2.7.7.490.531
3m8qDJZGag-Pol polyprotein2.7.7.490.530
1vruAAPGag-Pol polyprotein2.7.7.490.529
4h4o506Gag-Pol polyprotein2.7.7.490.522
1hpzAAPGag-Pol polyprotein2.7.7.490.521
2ze2T27Gag-Pol polyprotein2.7.7.490.520
3dyaPZLGag-Pol polyprotein2.7.7.490.515
3e01PZ2Gag-Pol polyprotein2.7.7.490.515
2be2R22Gag-Pol polyprotein2.7.7.490.514
1hquHBYGag-Pol polyprotein2.7.7.490.513
3lakKR1Gag-Pol polyprotein2.7.7.490.513
2ic3HBYGag-Pol polyprotein2.7.7.490.512
2rkiTT1Gag-Pol polyprotein2.7.7.490.512
3c6tM14Gag-Pol polyprotein2.7.7.490.512
2ynfWHUGag-Pol polyprotein2.7.7.490.510
3t195MAGag-Pol polyprotein2.7.7.490.509
1s1vTNKGag-Pol polyprotein2.7.7.490.507
1s1tUC1Gag-Pol polyprotein2.7.7.490.506
4ko0JLJGag-Pol polyprotein2.7.7.490.506
1tktH12Gag-Pol polyprotein2.7.7.490.505
3t1a5MAGag-Pol polyprotein2.7.7.490.505
1tkzH16Gag-Pol polyprotein2.7.7.490.504
1revTB9Gag-Pol polyprotein2.7.7.490.501
3di6PDZGag-Pol polyprotein2.7.7.490.501
1ep4S11Gag-Pol polyprotein2.7.7.490.500
1s1wUC1Gag-Pol polyprotein2.7.7.490.500
1rt7UC4Gag-Pol polyprotein2.7.7.490.497
3drpR8EGag-Pol polyprotein2.7.7.490.497
2ban357Gag-Pol polyprotein2.7.7.490.496
1hniAAAGag-Pol polyprotein2.7.7.490.490
4i2q1BTGag-Pol polyprotein2.7.7.490.489
4kko1REGag-Pol polyprotein2.7.7.490.487
1ikwEFZGag-Pol polyprotein2.7.7.490.486
1s9eADBGag-Pol polyprotein2.7.7.490.486
1hnvTBOGag-Pol polyprotein2.7.7.490.481
5cyqT27Gag-Pol polyprotein2.7.7.490.479
2vg7NNIGag-Pol polyprotein2.7.7.490.478
1tkxGWBGag-Pol polyprotein2.7.7.490.477
3tamM06Gag-Pol polyprotein2.7.7.490.475
1ikyMSDGag-Pol polyprotein2.7.7.490.472
4c2xNHWGlycylpeptide N-tetradecanoyltransferase 2/0.471
4ig3T27Gag-Pol polyprotein2.7.7.490.469
5ag6MYAGlycylpeptide N-tetradecanoyltransferase/0.465
1eetBFUGag-Pol polyprotein2.7.7.490.462
2opqHBQGag-Pol polyprotein2.7.7.490.461
2ynhEURGag-Pol polyprotein2.7.7.490.461
4g1qT27Gag-Pol polyprotein2.7.7.490.461
1fp1HCCIsoliquiritigenin 2'-O-methyltransferase/0.459
4cgpMYAGlycylpeptide N-tetradecanoyltransferase/0.459
3u8hBHPPhospholipase A2, membrane associated/0.458
3be9P04Casein kinase II subunit alpha2.7.11.10.457
1c1c612Gag-Pol polyprotein2.7.7.490.456
3p99LNPLanosterol 14-alpha-demethylase/0.456
4a33MYAGlycylpeptide N-tetradecanoyltransferase/0.456
5ag7MYAGlycylpeptide N-tetradecanoyltransferase/0.456
2yneNHWGlycylpeptide N-tetradecanoyltransferase/0.454
1ezvSMACytochrome b/0.453
4a95NHWGlycylpeptide N-tetradecanoyltransferase/0.453
4mv1ADPBiotin carboxylase6.3.4.140.453
4nc3ERM5-hydroxytryptamine receptor 2B/0.452
5a27MYAGlycylpeptide N-tetradecanoyltransferase/0.451
1fk9EFZGag-Pol polyprotein2.7.7.490.450
4a32MYAGlycylpeptide N-tetradecanoyltransferase/0.449
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.449
1lwlDSOCamphor 5-monooxygenase1.14.15.10.448
3p3zP3ZPutative cytochrome P450/0.448
4rw4494Gag-Pol polyprotein2.7.7.490.448
2oprHBQGag-Pol polyprotein2.7.7.490.447
4b12NHWGlycylpeptide N-tetradecanoyltransferase/0.447
1jlqSBNGag-Pol polyprotein2.7.7.490.446
2rf2MRXGag-Pol polyprotein2.7.7.490.446
3m8p65BGag-Pol polyprotein2.7.7.490.446
1ikxPNUGag-Pol polyprotein2.7.7.490.445
1xddAAYIntegrin alpha-L/0.445
2vqoTFGHistone deacetylase 43.5.1.980.444
3qtzX42Cyclin-dependent kinase 22.7.11.220.444
4b10NHWGlycylpeptide N-tetradecanoyltransferase/0.444
5k2bZMAAdenosine receptor A2a/0.444
2hndNVPGag-Pol polyprotein2.7.7.490.443
2w0bCMWLanosterol 14-alpha demethylase1.14.13.700.443
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.443
4z44FADFlavin-dependent tryptophan halogenase PrnA1.14.19.90.443
1rt5UC2Gag-Pol polyprotein2.7.7.490.442
2oyeIM8Prostaglandin G/H synthase 11.14.99.10.442
3t14FADSulfide-quinone reductase/0.442
1ppjANYCytochrome b/0.441
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.441
3t8xT8XT-cell surface glycoprotein CD1b/0.441
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.441