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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1orkATCTetracycline repressor protein class D

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1orkATCTetracycline repressor protein class D/1.000
4b3aTACTetracycline repressor protein class D/0.684
2xpvMIYTetracycline repressor protein class D/0.675
4auxXTCTetracycline repressor protein class D/0.666
5fkmTDCTetracycline repressor protein class D/0.644
2o7oDXTTetracycline repressor protein class D/0.641
5fklTDCTetracycline repressor protein class D/0.606
2tctCTCTetracycline repressor protein class D/0.603
2xpwOTCTetracycline repressor protein class D/0.602
4b1rITCTetracycline repressor protein class D/0.569
2xrlDXTTetracycline repressor protein class D/0.558
4v2gITCTetracycline repressor protein class D/0.551
4abzT1CTetracycline repressor protein class D/0.550
2fj1CTCTetracycline repressor protein class D/0.547
2xpuTDCTetracycline repressor protein class D/0.539
4d7mTDCTetracycline repressor protein class D/0.538
5fkoTDCTetracycline repressor protein class D/0.529
2trtTACTetracycline repressor protein class D/0.528
2vkeTACTetracycline repressor protein class D/0.528
2xb5I7TTetracycline repressor protein class D/0.527
4ac0MIYTetracycline repressor protein class B from transposon Tn10/0.515
5fknTDCTetracycline repressor protein class D/0.515
2x6o2TCTetracycline repressor protein class D/0.513
2vkvTDCTetracycline repressor protein class D/0.509
2x9dITCTetracycline repressor protein class D/0.501
2vprTDCTetracycline repressor protein class H/0.495