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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1oaaNAPSepiapterin reductase1.1.1.153

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1oaaNAPSepiapterin reductase1.1.1.1531.000
4j7xNAPSepiapterin reductase1.1.1.1530.642
4j7uNAPSepiapterin reductase1.1.1.1530.634
4hwkNAPSepiapterin reductase1.1.1.1530.613
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.534
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.534
1ipeNDPTropinone reductase 21.1.1.2360.532
5idwNAPShort-chain dehydrogenase/reductase SDR/0.530
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.526
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.518
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.516
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.513
1xg5NAPDehydrogenase/reductase SDR family member 11/0.512
1n5dNDPCarbonyl reductase [NADPH] 1/0.511
1snyNAPLD36273p/0.508
3l77NJPShort-chain alcohol dehydrogenase/0.504
2bd0NAPSepiapterin reductase/0.503
1ae1NAPTropinone reductase 1/0.500
3p19NDPPutative blue fluorescent protein/0.498
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.498
2yutNAPPutative short-chain oxidoreductase/0.496
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.494
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.488
4qecNAPElxO/0.487
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.486
4bmvNAPShort-chain dehydrogenase/0.485
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.484
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.483
1x7gNAPPutative ketoacyl reductase1.3.10.481
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.479
3tn7NJPShort-chain alcohol dehydrogenase/0.477
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.474
3gy0NAPNAD(P)-dependent oxidoreductase/0.473
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.471
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.470
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.470
2jahNDPClavaldehyde dehydrogenase/0.469
1pr9NAPL-xylulose reductase1.1.1.100.468
1w4zNAPPutative ketoacyl reductase1.3.10.468
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.466
4dc1NDPPutative ketoacyl reductase1.3.10.465
3f1kNAPUncharacterized oxidoreductase YciK10.463
3toxNAPPutative oxidoreductase/0.463
1wntNAPL-xylulose reductase1.1.1.100.461
3d3wNAPL-xylulose reductase1.1.1.100.460
1x7hNDPPutative ketoacyl reductase1.3.10.458
2dteNAIGlucose 1-dehydrogenase related protein/0.458
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.458
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.457
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.457
1xkqNDPUncharacterized protein/0.455
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.455
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.450
4qedNAPElxO/0.449
3qrwNDPPutative ketoacyl reductase1.3.10.448
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.447
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.446
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.446
3w8eNAD3-hydroxybutyrate dehydrogenase/0.445
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.443
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
4jbiNDPAlcohol dehydrogenase (Zinc)/0.443
5jydNADShort chain dehydrogenase/0.443
5jlaNADPutative short-chain dehydrogenase/reductase/0.440