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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1lvg5GPGuanylate kinase2.7.4.8

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1lvg5GPGuanylate kinase2.7.4.81.000
2anb5GPGuanylate kinase2.7.4.80.593
2j415GPGuanylate kinase/0.555
1ex75GPGuanylate kinase2.7.4.80.514
2xuoTZ4Acetylcholinesterase3.1.1.70.467
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.461
3rvhHQ2Lysine-specific demethylase 4A1.14.110.458
2jf0HBPAcetylcholinesterase3.1.1.70.456
3qfrFMNNADPH--cytochrome P450 reductase/0.453
4ohf5GPCytosolic IMP-GMP specific 5'-nucleotidase/0.451
2gesCOKPantothenate kinase2.7.1.330.449
3h3qH13Collagen type IV alpha-3-binding protein/0.449
4x81MVIMycinamicin III 3''-O-methyltransferase2.1.1.2370.446
4bqzGNPEctonucleoside triphosphate diphosphohydrolase 2/0.445
1a9cGTPGTP cyclohydrolase 13.5.4.160.444
1tllFMNNitric oxide synthase, brain1.14.13.390.443
2an9GDPGuanylate kinase2.7.4.80.443
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.443
3a1cACPProbable copper-exporting P-type ATPase A3.6.3.540.443
5hg0SAMPantothenate synthetase/0.442
5ah5LSSLeucine--tRNA ligase/0.440