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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1lldNADL-lactate dehydrogenase 21.1.1.27

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1lldNADL-lactate dehydrogenase 21.1.1.271.000
3kpkFADSulfide-quinone reductase/0.491
3t14FADSulfide-quinone reductase/0.491
3t2kFADSulfide-quinone reductase/0.486
3syiFADSulfide-quinone reductase/0.483
3sz0FADSulfide-quinone reductase/0.468
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.467
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.467
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.464
3gqvNAPEnoyl reductase LovC10.464
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.462
1e3eNAIAlcohol dehydrogenase 41.1.1.10.457
3qlsNDPDihydrofolate reductase1.5.1.30.455
3tqhNDPQuinone oxidoreductase/0.454
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.453
4ylfFADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit homolog/0.453
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.452
3t2yFADSulfide-quinone reductase/0.452
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
1jioDEB6-deoxyerythronolide B hydroxylase/0.451
1rfuADPPyridoxal kinase2.7.1.350.451
8dfrNDPDihydrofolate reductase1.5.1.30.450
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.449
3b6zCO7Enoyl reductase LovC10.449
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.449
1xe55FEPlasmepsin-23.4.23.390.448
3b70NAPEnoyl reductase LovC10.448
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
1ma0NADAlcohol dehydrogenase class-31.1.1.10.447
1nvtNAPShikimate dehydrogenase (NADP(+))/0.447
1qlhNADAlcohol dehydrogenase E chain1.1.1.10.447
3etgNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.447
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
4e5yNDPGDP-L-fucose synthase1.1.1.2710.446
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.445
2i3gNAPN-acetyl-gamma-glutamyl-phosphate reductase1.2.1.380.445
3qwbNDPProbable quinone oxidoreductase1.6.5.50.445
1yb5NAPQuinone oxidoreductase1.6.5.50.444
4b7sQLECytochrome P450 monooxygenase PikC/0.444
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
2fy4COACholine O-acetyltransferase2.3.1.60.443
3atzFMNProstaglandin F2a synthase/0.443
4q73FADBifunctional protein PutA/0.443
5hs1VORLanosterol 14-alpha demethylase/0.443
2c0cNAPProstaglandin reductase 310.441
2w3bNDPDihydrofolate reductase1.5.1.30.441
3t2zFADSulfide-quinone reductase/0.441
4lcg1WMUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.441
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1psa0ZLPepsin A3.4.23.10.440
2fzwNADAlcohol dehydrogenase class-31.1.1.10.440
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
4g7gVFVLanosterol 14-alpha-demethylase/0.440