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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1j1cADPGlycogen synthase kinase-3 beta2.7.11.26

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1j1cADPGlycogen synthase kinase-3 beta2.7.11.261.000
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.538
4qnyANPMitogen activated protein kinase, putative/0.502
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.489
5dnrATPAurora kinase A2.7.11.10.488
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.484
1qmzATPCyclin-dependent kinase 22.7.11.220.467
4ii5ADPCyclin-dependent kinase 22.7.11.220.465
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.459
4deeADPAurora kinase A2.7.11.10.457
4fv6E57Mitogen-activated protein kinase 12.7.11.240.457
5dosATPAurora kinase A2.7.11.10.456
4eooATPCyclin-dependent kinase 22.7.11.220.453
3i60E86Mitogen-activated protein kinase 12.7.11.240.452
4j95ACPFibroblast growth factor receptor 2/0.452
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.449
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.447
4aguD15Cyclin-dependent kinase-like 1/0.446
4btjATPTau-tubulin kinase 12.7.11.10.445
4ix5ANPUncharacterized protein/0.443
1ig1ANPDeath-associated protein kinase 12.7.11.10.440