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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1ig1ANPDeath-associated protein kinase 12.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1ig1ANPDeath-associated protein kinase 12.7.11.11.000
2w4jADPDeath-associated protein kinase 12.7.11.10.701
1jklANPDeath-associated protein kinase 12.7.11.10.683
1jkkANPDeath-associated protein kinase 12.7.11.10.620
4ysjADPCalmodulin-like domain protein kinase/0.526
4qnyANPMitogen activated protein kinase, putative/0.523
3gu7ADPDeath-associated protein kinase 12.7.11.10.493
5dnrATPAurora kinase A2.7.11.10.468
1qmzATPCyclin-dependent kinase 22.7.11.220.466
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.464
5dosATPAurora kinase A2.7.11.10.460
2yaaATPDeath-associated protein kinase 2/0.459
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.459
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.455
2cjmATPCyclin-dependent kinase 22.7.11.220.446
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.443
3c4wATPRhodopsin kinase/0.442