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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1i2lDCSAminodeoxychorismate lyase4.1.3.38

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1i2lDCSAminodeoxychorismate lyase4.1.3.381.000
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.477
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.474
5ej9TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.473
2eudGCQRibonucleoside-diphosphate reductase large chain 11.17.4.10.471
1pkfEPDEpothilone C/D epoxidase1.140.470
1nuqNXXNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.467
1adfTADAlcohol dehydrogenase E chain1.1.1.10.466
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.459
3adaNADSubunit alpha of sarocosine oxidase/0.457
5ejaTD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.457
1xddAAYIntegrin alpha-L/0.456
1iyzNDPProbable quinone oxidoreductase/0.455
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.455
3t5iSER_SER_CMT_FARRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.455
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.455
1kkq471Peroxisome proliferator-activated receptor alpha/0.454
3bl7DD1m7GpppX diphosphatase3.6.1.590.454
1kqwRTLCellular retinol-binding protein type II/0.452
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.452
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.452
3tzaTZGGlutamate receptor 2/0.452
4xgxADPFAD:protein FMN transferase/0.452
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.451
2po7CHDFerrochelatase, mitochondrial4.99.1.10.451
4jhz1KVBeta-glucuronidase3.2.1.310.451
5jy1NADPutative short-chain dehydrogenase/reductase/0.450
1j7lADPAminoglycoside 3'-phosphotransferase2.7.1.950.449
1xuoLA1Integrin alpha-L/0.448
3br3ETHTH-type transcriptional regulator QacR/0.448
3gw9VNILanosterol 14-alpha-demethylase/0.448
1zdwFLVPrenyltransferase/0.447
2npiATPmRNA cleavage and polyadenylation factor CLP1/0.447
3gyiFADCholesterol oxidase1.1.3.60.447
4j6cSTRCytochrome P450 monooxygenase/0.447
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.446
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.446
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
2xlsFADPutative flavin-containing monooxygenase/0.445
4y8vADPAcyl-CoA synthetase (NDP forming)/0.445
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.444
1pqc444Oxysterols receptor LXR-beta/0.444
1tw4CHDFatty acid-binding protein, liver/0.444
2hk9NAPShikimate dehydrogenase (NADP(+))/0.444
2ptfFMNUncharacterized protein MTH_863/0.444
4l9q9TPSerum albumin/0.444
1culFOKAdenylate cyclase type 2/0.443
1culFOKAdenylate cyclase type 5/0.443
1tllNAPNitric oxide synthase, brain1.14.13.390.443
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
3d84NDPDihydrofolate reductase1.5.1.30.443
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
4a4wYFBPeroxisome proliferator-activated receptor gamma/0.443
4bb3KKAIsopenicillin N synthase1.21.3.10.443
1w2xRCPAcetyl-CoA carboxylase/0.442
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.442
3g5hYTTMycocyclosin synthase1.14.21.90.442
3vrwYS5Vitamin D3 receptor/0.442
4g3jVNTLanosterol 14-alpha-demethylase/0.442
1cqp803Integrin alpha-L/0.441
1rkxNADCDP-D-glucose-4,6-dehydratase/0.441
1x2hLPALipoate-protein ligase A6.3.1.200.441
2bxiAZQSerum albumin/0.441
3hl0NADMaleylacetate reductase/0.441
4du82P0Mevalonate diphosphate decarboxylase/0.441
2p4yC03Peroxisome proliferator-activated receptor gamma/0.440
2tpsTPSThiamine-phosphate synthase/0.440
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
4a862ANMajor pollen allergen Bet v 1-A/0.440
4ia3BIVVitamin D3 receptor A/0.440
4ipw1G7Mycocyclosin synthase1.14.21.90.440
5d3fFSC14-3-3 protein zeta/delta/0.440