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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1fgiSU1Fibroblast growth factor receptor 1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1fgiSU1Fibroblast growth factor receptor 1/1.000
3uzcT4EAdenosine receptor A2a/0.493
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.489
3pwhZMAAdenosine receptor A2a/0.474
4elf35IDihydrofolate reductase/0.467
1blzACVIsopenicillin N synthase1.21.3.10.463
3w2cN15Aurora kinase A2.7.11.10.463
3a1l2CCCytochrome P450/0.459
3rfmCFFAdenosine receptor A2a/0.459
4jlk1NODeoxycytidine kinase2.7.1.740.458
3uzaT4GAdenosine receptor A2a/0.458
4fnyI3KALK tyrosine kinase receptor2.7.10.10.457
3zeiAWHO-acetylserine sulfhydrylase/0.456
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.456
1obnASVIsopenicillin N synthase1.21.3.10.455
3eta351Insulin receptor2.7.10.10.454
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.453
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.452
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.452
4at3LTIBDNF/NT-3 growth factors receptor2.7.10.10.452
2y60M8FIsopenicillin N synthase1.21.3.10.451
4ib4ERM5-hydroxytryptamine receptor 2B/0.451
4v010LIFibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b/0.449
3d5fL41Peroxisome proliferator-activated receptor delta/0.448
3jzmATPCircadian clock protein kinase KaiC2.7.11.10.448
4nks2M2Fibroblast growth factor receptor 1/0.448
3vo30KFVascular endothelial growth factor receptor 22.7.10.10.447
4nk92K5Fibroblast growth factor receptor 1/0.446
4tyj0LIFibroblast growth factor receptor 42.7.10.10.446
3e5aVX6Aurora kinase A2.7.11.10.445
3k0fATPCircadian clock protein kinase KaiC2.7.11.10.445
3mlaJJZProbable nicotinate-nucleotide adenylyltransferase/0.445
4iaq2GM5-hydroxytryptamine receptor 1B/0.445
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.445
3l6jZ90Alr2278 protein/0.444
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.444
4bbhNHWGlycylpeptide N-tetradecanoyltransferase/0.444
1oc1ASVIsopenicillin N synthase1.21.3.10.443
1tf7ATPCircadian clock protein kinase KaiC2.7.11.10.443
2po7CHDFerrochelatase, mitochondrial4.99.1.10.443
4iae1DXAlr2278 protein/0.443
4phlPILPhosphodiesterase/0.443
2j4z626Aurora kinase A2.7.11.10.442
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.442
4jqh1MFAlr2278 protein/0.442
3reyXACAdenosine receptor A2a/0.442
1u9iATPCircadian clock protein kinase KaiC2.7.11.10.441
2og81N8Tyrosine-protein kinase Lck2.7.10.20.441
3abaFLICytochrome P450/0.441
1gqtACPRibokinase/0.440
4b8mVX6Aurora kinase B-A2.7.11.10.440