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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1e2lTMCThymidine kinase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1e2lTMCThymidine kinase/1.000
4ivqI43Thymidine kinase/0.490
1e2nRCAThymidine kinase/0.482
4jbxSK7Thymidine kinase/0.465
1e2jTHMThymidine kinase/0.461
2vbpVB1Isopenicillin N synthase1.21.3.10.461
2bjsACVIsopenicillin N synthase1.21.3.10.452
4bfwZVWPantothenate kinase2.7.1.330.452
1yw8A75Methionine aminopeptidase 2/0.451
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
1bk0ACVIsopenicillin N synthase1.21.3.10.447
2j3qTFLAcetylcholinesterase3.1.1.70.447
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.447
2vqsBVDDeoxynucleoside kinase/0.446
3d80Q22Dihydrofolate reductase1.5.1.30.446
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.445
1s3uTQDDihydrofolate reductase1.5.1.30.444
1pd9CO4Dihydrofolate reductase1.5.1.30.443
3zkyWT4Isopenicillin N synthase1.21.3.10.443
2vcmM11Isopenicillin N synthase1.21.3.10.442
1p72THMThymidine kinase/0.441
3rl45GPMetallophosphoesterase MPPED23.10.441
4bb3KKAIsopenicillin N synthase1.21.3.10.441
4iarERM5-hydroxytryptamine receptor 1B/0.441
1zgbA1EAcetylcholinesterase3.1.1.70.440
3zoiM2WIsopenicillin N synthase1.21.3.10.440