scPDB - Distribution of Binding site Similarity values of 1dyi entry / Site 2

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1dyi	FOL	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
1dyi	FOL	Dihydrofolate reductase	1.5.1.3	1.000
4dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.719
1dyh	DZF	Dihydrofolate reductase	1.5.1.3	0.705
1dhj	MTX	Dihydrofolate reductase	1.5.1.3	0.660
1dra	MTX	Dihydrofolate reductase	1.5.1.3	0.645
1jol	FFO	Dihydrofolate reductase	1.5.1.3	0.643
1dyj	DDF	Dihydrofolate reductase	1.5.1.3	0.636
2drc	MTX	Dihydrofolate reductase	1.5.1.3	0.635
1re7	FOL	Dihydrofolate reductase	1.5.1.3	0.633
3och	2MX	Dihydrofolate reductase	1.5.1.3	0.627
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.624
1rb2	FOL	Dihydrofolate reductase	1.5.1.3	0.616
1ddr	MTX	Dihydrofolate reductase	1.5.1.3	0.611
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.601
5hi6	MTX	Dihydrofolate reductase	/	0.595
4x5i	FOL	Dihydrofolate reductase	1.5.1.3	0.593
1drb	MTX	Dihydrofolate reductase	1.5.1.3	0.589
1dhi	MTX	Dihydrofolate reductase	1.5.1.3	0.580
3drc	MTX	Dihydrofolate reductase	1.5.1.3	0.580
4x5j	FOL	Dihydrofolate reductase	1.5.1.3	0.576
1ra3	MTX	Dihydrofolate reductase	1.5.1.3	0.573
1ra8	FOL	Dihydrofolate reductase	1.5.1.3	0.568
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.568
1tdr	MTX	Dihydrofolate reductase	1.5.1.3	0.564
1rd7	FOL	Dihydrofolate reductase	1.5.1.3	0.557
4x5h	FOL	Dihydrofolate reductase	1.5.1.3	0.544
1rx8	FOL	Dihydrofolate reductase	1.5.1.3	0.543
1rx7	FOL	Dihydrofolate reductase	1.5.1.3	0.537
1rf7	DHF	Dihydrofolate reductase	1.5.1.3	0.526
1rx5	DDF	Dihydrofolate reductase	1.5.1.3	0.513
2d0k	FOL	Dihydrofolate reductase	1.5.1.3	0.511
1rc4	DDF	Dihydrofolate reductase	1.5.1.3	0.504
2w9s	TOP	Dihydrofolate reductase type 1 from Tn4003	1.5.1.3	0.501
3oaf	OAG	Dihydrofolate reductase	1.5.1.3	0.495
5ccc	DDF	Dihydrofolate reductase	1.5.1.3	0.489
1s3v	TQD	Dihydrofolate reductase	1.5.1.3	0.488
1dr3	HBI	Dihydrofolate reductase	1.5.1.3	0.486
1ao8	MTX	Dihydrofolate reductase	1.5.1.3	0.484
4ej1	FOL	Dihydrofolate reductase	1.5.1.3	0.484
4i13	FOL	Dihydrofolate reductase	1.5.1.3	0.476
1jio	DEB	6-deoxyerythronolide B hydroxylase	/	0.468
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.468
1diu	BDM	Dihydrofolate reductase	1.5.1.3	0.467
3irm	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.467
1ia4	TQ6	Dihydrofolate reductase	1.5.1.3	0.463
1u71	MXA	Dihydrofolate reductase	1.5.1.3	0.457
3s7a	684	Dihydrofolate reductase	1.5.1.3	0.453
4i1n	FOL	Dihydrofolate reductase	1.5.1.3	0.452
4kne	1CY	Dihydrofolate reductase	1.5.1.3	0.449
1rx6	DDF	Dihydrofolate reductase	1.5.1.3	0.448
4elb	34S	Dihydrofolate reductase	/	0.447
4uym	VOR	14-alpha sterol demethylase Cyp51B	/	0.447
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.446
1ia3	TQ5	Dihydrofolate reductase	1.5.1.3	0.445
1qbg	FAD	NAD(P)H dehydrogenase [quinone] 1	1.6.5.2	0.445
4g95	OAG	Dihydrofolate reductase	1.5.1.3	0.445
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.444
1vzd	CB3	Thymidylate synthase	/	0.440