sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1dub | CAA | Enoyl-CoA hydratase, mitochondrial | 4.2.1.17 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1dub | CAA | Enoyl-CoA hydratase, mitochondrial | 4.2.1.17 | 1.000 | |
| 1mj3 | HXC | Enoyl-CoA hydratase, mitochondrial | 4.2.1.17 | 0.635 | |
| 3q0g | COA | Probable enoyl-CoA hydratase echA8 | 4.2.1.17 | 0.620 | |
| 1ey3 | DAK | Enoyl-CoA hydratase, mitochondrial | 4.2.1.17 | 0.618 | |
| 2dub | CO8 | Enoyl-CoA hydratase, mitochondrial | 4.2.1.17 | 0.571 | |
| 3q0g | BCO | Probable enoyl-CoA hydratase echA8 | 4.2.1.17 | 0.566 | |
| 1nzy | BCA | 4-chlorobenzoyl coenzyme A dehalogenase | 3.8.1.7 | 0.550 | |
| 1jxz | BCA | 4-chlorobenzoyl coenzyme A dehalogenase | 3.8.1.7 | 0.546 | |
| 5aaj | HSC | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.543 | |
| 4qij | 1HA | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.489 | |
| 3cx5 | SMA | Cytochrome b | / | 0.485 | |
| 5bt4 | 2LO | Bromodomain-containing protein 4 | / | 0.474 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.473 | |
| 1kyo | SMA | Cytochrome b | / | 0.472 | |
| 3cxh | SMA | Cytochrome b | / | 0.471 | |
| 2qjy | SMA | Cytochrome b | / | 0.470 | |
| 4i42 | 1HA | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.465 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.464 | |
| 2wle | COA | Polysialic acid O-acetyltransferase | / | 0.464 | |
| 3a0i | AJI | Glucokinase | 2.7.1.2 | 0.463 | |
| 4xwr | FAD | Cholesterol oxidase | 1.1.3.6 | 0.459 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.458 | |
| 2yiu | SMA | Cytochrome b | / | 0.458 | |
| 3t88 | S0N | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.457 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.457 | |
| 1ezv | SMA | Cytochrome b | / | 0.456 | |
| 2ibz | SMA | Cytochrome b | / | 0.456 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
| 4xxg | FAD | Cholesterol oxidase | 1.1.3.6 | 0.456 | |
| 1p7t | ACO | Malate synthase G | / | 0.455 | |
| 3gwn | FAD | Probable FAD-linked sulfhydryl oxidase R596 | 1.8.3.2 | 0.455 | |
| 4mle | VO1 | Glucokinase | 2.7.1.2 | 0.455 | |
| 1xuo | LA1 | Integrin alpha-L | / | 0.454 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 1n4u | FAE | Cholesterol oxidase | 1.1.3.6 | 0.453 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.452 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.452 | |
| 4xuh | SFI | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.451 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.451 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.449 | |
| 1mxt | FAE | Cholesterol oxidase | 1.1.3.6 | 0.447 | |
| 3oia | A31 | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 1nde | MON | Estrogen receptor beta | / | 0.446 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.446 | |
| 2wet | FAD | Tryptophan 5-halogenase | / | 0.446 | |
| 3vso | EK1 | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.446 | |
| 1q51 | CAA | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.445 | |
| 3aba | FLI | Cytochrome P450 | / | 0.445 | |
| 4ejn | 0R4 | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.445 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.444 | |
| 2ze2 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 3l9m | L9M | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.444 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.443 | |
| 1olm | VTQ | SEC14-like protein 2 | / | 0.442 | |
| 1ybg | TAV | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.442 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.442 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.442 | |
| 4iah | 1DX | Alr2278 protein | / | 0.442 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2qjp | SMA | Cytochrome b | / | 0.441 | |
| 3iw1 | ASD | Steroid C26-monooxygenase | 1.14.13.141 | 0.441 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.441 | |
| 1cc2 | FAD | Cholesterol oxidase | 1.1.3.6 | 0.440 | |
| 3rhh | NAP | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | / | 0.440 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.440 | |
| 4u2l | SFD | Cholesterol oxidase | 1.1.3.6 | 0.440 |