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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1b5eDCMDeoxycytidylate 5-hydroxymethyltransferase2.1.2.8

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1b5eDCMDeoxycytidylate 5-hydroxymethyltransferase2.1.2.81.000
1b5dDCMDeoxycytidylate 5-hydroxymethyltransferase2.1.2.80.782
4dq1UMPThymidylate synthase/0.464
1f28UMPThymidylate synthase2.1.1.450.459
3bgxMEFThymidylate synthase/0.454
4foxUMPThymidylate synthase ThyA/0.453
2qjoNADBifunctional NMN adenylyltransferase/Nudix hydrolase2.7.7.10.449
4einNOHThymidylate synthase2.1.1.450.448
1jmgUMPThymidylate synthase/0.444
3gegNADShort-chain dehydrogenase/reductase SDR/0.443
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.442
3bgxTMPThymidylate synthase/0.442
4iskUMPThymidylate synthase/0.442
4nbwNADShort-chain dehydrogenase/reductase SDR/0.442