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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1akwFMNFlavodoxin

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1akwFMNFlavodoxin/1.000
1akrFMNFlavodoxin/0.632
1azlFMNFlavodoxin/0.581
1bu5RBFFlavodoxin/0.572
5xraFMNCannabinoid receptor 1/0.572
5fx2FMNFlavodoxin/0.555
1fx1FMNFlavodoxin/0.551
3f6rFMNFlavodoxin/0.549
1j9gFMNFlavodoxin/0.545
1c7fFMNFlavodoxin/0.536
1j8qFMNFlavodoxin/0.533
1akuFMNFlavodoxin/0.525
3ojxFMNNADPH--cytochrome P450 reductase/0.519
2fx2FMNFlavodoxin/0.507
1wsbFMNFlavodoxin/0.506
4y7cFMNNADPH--cytochrome P450 reductase/0.501
1ykgFMNSulfite reductase [NADPH] flavoprotein alpha-component/0.497
5tgzFMNCannabinoid receptor 1/0.496
3f6sFMNFlavodoxin/0.494
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.489
1xyvFMNFlavodoxin/0.488
1xyyFMNFlavodoxin/0.478
2fcrFMNFlavodoxin/0.472
3q9bB3NAcetylpolyamine amidohydrolase/0.472
4n82FMNRibonucleotide reductase (NrdI family protein), putative/0.461
4fx2FMNFlavodoxin/0.460
3mhpFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.458
3reoSAH(Iso)eugenol O-methyltransferase2.1.1.1460.456
2v13C40Renin3.4.23.150.455
1blzACVIsopenicillin N synthase1.21.3.10.451
1ja0FMNNADPH--cytochrome P450 reductase/0.451
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.450
1obnASVIsopenicillin N synthase1.21.3.10.449
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
1j9zFMNNADPH--cytochrome P450 reductase/0.448
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.448
2g8yNADHydroxycarboxylate dehydrogenase B/0.447
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
1ofvFMNFlavodoxin/0.444
1ahnFMNFlavodoxin 1/0.442
1cf3FADGlucose oxidase1.1.3.40.442
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.442
4dpf0LGBeta-secretase 13.4.23.460.442
1zgcA2EAcetylcholinesterase3.1.1.70.441
2aotSAHHistamine N-methyltransferase2.1.1.80.441
2idkC2FGlycine N-methyltransferase2.1.1.200.441
2r6hFADNa(+)-translocating NADH-quinone reductase subunit F/0.441
1mxtFAECholesterol oxidase1.1.3.60.440
2mokFMNFlavodoxin 1/0.440
3fktSIIBeta-secretase 13.4.23.460.440
3kaqFMNFlavodoxin/0.440
4necSAHPutative SAM-dependent methyltransferase/0.440