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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
8mht SAH Modification methylase HhaI 2.1.1.37

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
8mht SAHModification methylase HhaI 2.1.1.37 0.922
9mht SAHModification methylase HhaI 2.1.1.37 0.866
7mht SAHModification methylase HhaI 2.1.1.37 0.850
5mht SAHModification methylase HhaI 2.1.1.37 0.837
10mh SAHModification methylase HhaI 2.1.1.37 0.836
2uyh SAHModification methylase HhaI 2.1.1.37 0.830
1skm SAHModification methylase HhaI 2.1.1.37 0.789
3mht SAHModification methylase HhaI 2.1.1.37 0.786
2c7q SAHModification methylase HhaI 2.1.1.37 0.779
4mht SAHModification methylase HhaI 2.1.1.37 0.776
2zcj SAHModification methylase HhaI 2.1.1.37 0.757
2i9k SAHModification methylase HhaI 2.1.1.37 0.746
2z6u SAHModification methylase HhaI 2.1.1.37 0.729
3qv2 SAH5-cytosine DNA methyltransferase / 0.709
2hmy SAMModification methylase HhaI 2.1.1.37 0.703
1g60 SAMModification methylase MboII 2.1.1.72 0.697
4rtk SAHDNA adenine methylase 2.1.1.72 0.697
2dpm SAMModification methylase DpnIIA 2.1.1.72 0.695
3swr SFGDNA (cytosine-5)-methyltransferase 1 2.1.1.37 0.695
1nw5 SAMModification methylase RsrI 2.1.1.72 0.694
2okc SAMProbable type I restriction enzyme BthVORF4518P M protein 2.1.1.72 0.694
2g1p SAHDNA adenine methylase 2.1.1.72 0.690
1mht SAHModification methylase HhaI 2.1.1.37 0.683
1ori SAHProtein arginine N-methyltransferase 1 / 0.679
1boo SAHModification methylase PvuII 2.1.1.113 0.678
4poo SAMPutative RNA methylase / 0.678
4gbe SAHDNA adenine methylase 2.1.1.72 0.676
2px2 SAHGenome polyprotein 2.7.7.48 0.671
2yx1 SFGtRNA (guanine(37)-N1)-methyltransferase Trm5b 2.1.1.228 0.670
3pt6 SAHDNA (cytosine-5)-methyltransferase 1 2.1.1.37 0.667
3eey SAMrRNA methylase / 0.666
3ldg SAHUncharacterized protein / 0.663
3a27 SAMtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase / 0.662
4fzv SAM5-methylcytosine rRNA methyltransferase NSUN4 2.1.1 0.661
3axt SAMtRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase / 0.660
4dkj SAHCytosine-specific methyltransferase / 0.660
1wg8 SAMRibosomal RNA small subunit methyltransferase H / 0.659
4rtj SFGDNA adenine methylase 2.1.1.72 0.659
5bxy SAHPutative RNA methylase family UPF0020 / 0.658
2zul SAMProbable ribosomal RNA small subunit methyltransferase / 0.657
2zif SAMMethyltransferase / 0.656
3a26 MTAtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase / 0.656
3dmg SAHProbable ribosomal RNA small subunit methyltransferase / 0.651
3ldf SAHUncharacterized protein / 0.651
1eg2 MTAModification methylase RsrI 2.1.1.72 0.650