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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5l6w AGS LIM domain kinase 1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5l6w AGSLIM domain kinase 1 2.7.11.1 0.840
1jst ATPCyclin-dependent kinase 2 2.7.11.22 0.699
1ir3 ANPInsulin receptor 2.7.10.1 0.667
2pwl ACPFibroblast growth factor receptor 2 / 0.666
1ol7 ADPAurora kinase A 2.7.11.1 0.665
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.665
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.665
5dr2 ATPAurora kinase A 2.7.11.1 0.665
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.664
1ol5 ADPAurora kinase A 2.7.11.1 0.662
4dee ADPAurora kinase A 2.7.11.1 0.660
4e5f 0N7Polymerase acidic protein / 0.660
1fq1 ATPCyclin-dependent kinase 2 2.7.11.22 0.656
5dt3 ATPAurora kinase A 2.7.11.1 0.656
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.654
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.652
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.652
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.651
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.651
2itn ANPEpidermal growth factor receptor 2.7.10.1 0.650
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650