Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5hes 032 Mitogen-activated protein kinase kinase kinase 20 2.7.11.25

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5hes 032Mitogen-activated protein kinase kinase kinase 20 2.7.11.25 1.107
4fk3 325Serine/threonine-protein kinase B-raf 2.7.11.1 0.768
4fv9 E71Mitogen-activated protein kinase 1 2.7.11.24 0.706
3mtf A3FActivin receptor type-1 2.7.11.30 0.694
1qpe PP2Tyrosine-protein kinase Lck 2.7.10.2 0.680
3bi6 396Wee1-like protein kinase 2.7.10.2 0.679
2gcd STUSerine/threonine-protein kinase TAO2 2.7.11.1 0.677
3biz 61EWee1-like protein kinase 2.7.10.2 0.676
3hdm MMGSerine/threonine-protein kinase Sgk1 2.7.11.1 0.667
3ppk FNISerine/threonine-protein kinase B-raf 2.7.11.1 0.664
3cqe P91Wee1-like protein kinase 2.7.10.2 0.662
3cr0 809Wee1-like protein kinase 2.7.10.2 0.662
1yol S03Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.661
2z2w 770Wee1-like protein kinase 2.7.10.2 0.659
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.655
2io6 330Wee1-like protein kinase 2.7.10.2 0.654
2yn8 STUEphrin type-B receptor 4 2.7.10.1 0.653
1qcf PP1Tyrosine-protein kinase HCK 2.7.10.2 0.652
3zls 92PDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.652