Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5e8w STU TGF-beta receptor type-1 2.7.11.30

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5e8w STUTGF-beta receptor type-1 2.7.11.30 1.008
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.895
5e8y STUTGF-beta receptor type-2 2.7.11.30 0.847
1yvj 4STTyrosine-protein kinase JAK3 2.7.10.2 0.801
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.790
2j0k 4STFocal adhesion kinase 1 2.7.10.2 0.784
4c34 STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.782
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.777
4mvf STUCalcium-dependent protein kinase 2 2.7.11.1 0.773
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.768
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.767
1byg STUTyrosine-protein kinase CSK / 0.766
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.764
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.757
2gcd STUSerine/threonine-protein kinase TAO2 2.7.11.1 0.751
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.749
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.747
2yn8 STUEphrin type-B receptor 4 2.7.10.1 0.747
4e5i 0N9Polymerase acidic protein / 0.744
4u9a STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.741
1xjd STUProtein kinase C theta type 2.7.11.13 0.740
3d7t STUTyrosine-protein kinase CSK / 0.737
1nxk STUMAP kinase-activated protein kinase 2 2.7.11.1 0.734
4fr4 STUSerine/threonine-protein kinase 32A 2.7.11.1 0.732
3l8p 0CEAngiopoietin-1 receptor 2.7.10.1 0.728
5e8x STUTGF-beta receptor type-1 2.7.11.30 0.728
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.727
2hy8 1STSerine/threonine-protein kinase PAK 1 2.7.11.1 0.726
1oky STU3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.725
2j0j 4STFocal adhesion kinase 1 2.7.10.2 0.721
4u97 STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.720
3a4o STUTyrosine-protein kinase Lyn 2.7.10.2 0.716
3a62 STURibosomal protein S6 kinase beta-1 2.7.11.1 0.715
2in6 839Wee1-like protein kinase 2.7.10.2 0.714
4qmy STUSerine/threonine-protein kinase 24 2.7.11.1 0.706
1p2a 5BNCyclin-dependent kinase 2 2.7.11.22 0.701
1stc STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.696
4erw STUCyclin-dependent kinase 2 2.7.11.22 0.692
4kik KSAInhibitor of nuclear factor kappa-B kinase subunit beta 2.7.11.10 0.686
4mcv 29KProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.683
4acg 6LQGlycogen synthase kinase-3 beta 2.7.11.26 0.682
2buj STUSerine/threonine-protein kinase 16 / 0.680
3zm4 22TDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.680
2j0m 4STFocal adhesion kinase 1 2.7.10.2 0.678
3ckx STUSerine/threonine-protein kinase 24 2.7.11.1 0.675
3zls 92PDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.674
3zew STUEphrin type-B receptor 4 2.7.10.1 0.670
1e9h INRCyclin-dependent kinase 2 2.7.11.22 0.668
4e5f 0N7Polymerase acidic protein / 0.660
4fkp LS5Cyclin-dependent kinase 2 2.7.11.22 0.660
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 0.654
1qpj STUTyrosine-protein kinase Lck 2.7.10.2 0.651
2xp2 VGHALK tyrosine kinase receptor 2.7.10.1 0.651
3biz 61EWee1-like protein kinase 2.7.10.2 0.651
4agc AXIVascular endothelial growth factor receptor 2 2.7.10.1 0.651
1x8b 824Wee1-like protein kinase 2.7.10.2 0.650
4ag8 AXIVascular endothelial growth factor receptor 2 2.7.10.1 0.650