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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5dr9 SKE Aurora kinase A 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5dr9 SKEAurora kinase A 2.7.11.1 1.000
5dr6 SKEAurora kinase A 2.7.11.1 0.899
5dt0 SKEAurora kinase A 2.7.11.1 0.893
5dpv SKEAurora kinase A 2.7.11.1 0.875
3uo5 0BXAurora kinase A 2.7.11.1 0.713
3ama SKEcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.712
4dea NHIAurora kinase A 2.7.11.1 0.712
2x81 ZZLAurora kinase A 2.7.11.1 0.702
4qmu SKESerine/threonine-protein kinase 24 2.7.11.1 0.681
3rk7 08ZCyclin-dependent kinase 2 2.7.11.22 0.672
1oec AA2Fibroblast growth factor receptor 2 / 0.671
4bbe 3O4Tyrosine-protein kinase JAK2 / 0.671
2j4z 626Aurora kinase A 2.7.11.1 0.663
3rkb 12ZCyclin-dependent kinase 2 2.7.11.22 0.661
1y57 MPZProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.658
2w1g L0GAurora kinase A 2.7.11.1 0.657
3k5u PFQAurora kinase A 2.7.11.1 0.654
2bdf 24AProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.651
2izs BRQCasein kinase I isoform gamma-3 2.7.11.1 0.650