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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5dgz L20 Serine/threonine-protein kinase pim-1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5dgz L20Serine/threonine-protein kinase pim-1 2.7.11.1 1.222
3kkv B99cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.835
2uzw SS4cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.774
2jdv L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.769
2uzt SS3cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.754
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2oh0 2PYcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.739
2ojf 4PYcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.712
2jds L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.710
2obj VRVSerine/threonine-protein kinase pim-1 2.7.11.1 0.686
3hzt J60Calmodulin-like domain protein kinase isoform 3 / 0.672
3cxw 7CPSerine/threonine-protein kinase pim-1 2.7.11.1 0.666
4jv8 1M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta / 0.661
4e5f 0N7Polymerase acidic protein / 0.660
3q9w EMOCasein kinase II subunit alpha 2.7.11.1 0.657
3r04 UNQSerine/threonine-protein kinase pim-1 2.7.11.1 0.657
4a7c E46Serine/threonine-protein kinase pim-1 2.7.11.1 0.654
4mq1 2C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A 2.7.12.1 0.654
5av4 GENDeath-associated protein kinase 1 2.7.11.1 0.654
2xbj XBJSerine/threonine-protein kinase Chk2 2.7.11.1 0.653
4a86 2ANMajor pollen allergen Bet v 1-A / 0.652