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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5amn DTQ Proto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5amn DTQProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 1.126
2ivu ZD6Proto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.837
2itz IREEpidermal growth factor receptor 2.7.10.1 0.784
2vwu 7X1Ephrin type-B receptor 4 2.7.10.1 0.775
4i22 IREEpidermal growth factor receptor 2.7.10.1 0.763
2h8h H8HProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.761
3f5p 741Insulin-like growth factor 1 receptor 2.7.10.1 0.756
4otw DB8Receptor tyrosine-protein kinase erbB-3 2.7.10.1 0.735
4mxo DB8Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.727
4g2f C07Ephrin type-A receptor 3 2.7.10.1 0.725
4ase AV9Vascular endothelial growth factor receptor 2 2.7.10.1 0.719
4qmn DB8Serine/threonine-protein kinase 24 2.7.11.1 0.714
4mxy DB8Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.699
4mxz DB8Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.699
3b8r 887Vascular endothelial growth factor receptor 2 2.7.10.1 0.696
1m17 AQ4Epidermal growth factor receptor 2.7.10.1 0.692
2xir 00JVascular endothelial growth factor receptor 2 2.7.10.1 0.681
4gk2 L66Ephrin type-A receptor 3 2.7.10.1 0.680
2x9f X9FEphrin type-B receptor 4 2.7.10.1 0.679
2c0i L1GTyrosine-protein kinase HCK 2.7.10.2 0.677
4e5l DBHPolymerase acidic protein / 0.676
3w55 1FMMitogen-activated protein kinase 1 2.7.11.24 0.675
2b7a IZATyrosine-protein kinase JAK2 / 0.673
4fyn 0VETyrosine-protein kinase SYK 2.7.10.2 0.670
1yhs STUSerine/threonine-protein kinase pim-1 2.7.11.1 0.664
2vwz 7X6Ephrin type-B receptor 4 2.7.10.1 0.660
4btk DTQTau-tubulin kinase 1 2.7.11.1 0.657
4f65 0S9Fibroblast growth factor receptor 1 / 0.656
4hjo AQ4Epidermal growth factor receptor 2.7.10.1 0.656
2jc6 QPPCalcium/calmodulin-dependent protein kinase type 1D 2.7.11.17 0.654
3vrz VRZTyrosine-protein kinase HCK 2.7.10.2 0.654
4c3f 7KWTyrosine-protein kinase Lck 2.7.10.2 0.653
3tub FPUTyrosine-protein kinase SYK 2.7.10.2 0.652
3b8q 900Vascular endothelial growth factor receptor 2 2.7.10.1 0.650
3vrw YS5Vitamin D3 receptor / 0.650