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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4y8w STR Steroid 21-hydroxylase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4y8w STRSteroid 21-hydroxylase / 1.018
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1m3q ANGN-glycosylase/DNA lyase 3.2.2 0.744
1v2h GUNPurine nucleoside phosphorylase 2.4.2.1 0.744
2puc GUNHTH-type transcriptional repressor PurR / 0.744
4e5l DBHPolymerase acidic protein / 0.744
3cas ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.715
2cbo TH2Neocarzinostatin / 0.686
3bur TES3-oxo-5-beta-steroid 4-dehydrogenase / 0.677
3iw1 ASDSteroid C26-monooxygenase 1.14.13.141 0.676
1gwr ESTEstrogen receptor / 0.675
2yja ESTEstrogen receptor / 0.670
4pxm ESTEstrogen receptor / 0.670
3oll ESTEstrogen receptor beta / 0.669
2j7x ESTEstrogen receptor beta / 0.664
2ocf ESTEstrogen receptor / 0.664
4j6d TESCytochrome P450 monooxygenase / 0.664
1ozq PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1p0e PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2pot GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2pwu GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2z1x PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4gcx PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4h7z GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hqv QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hvx QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4q0a 4OAVitamin D3 receptor A / 0.659
1lri CLRBeta-elicitin cryptogein / 0.656
2mm3 GCHGastrotropin / 0.656
3w5q 3KLVitamin D3 receptor / 0.655
3uzz ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.654
4jbt ASDCytochrome P450 monooxygenase / 0.654
2qgt EEDEstrogen receptor / 0.651