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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4xye NAD Formate dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4xye NADFormate dehydrogenase / 1.215
4xyb NDPFormate dehydrogenase / 1.111
2nad NADFormate dehydrogenase / 1.040
2gsd NADFormate dehydrogenase / 0.937
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.789
4weq NAPNAD-dependent dehydrogenase / 0.760
4z0p NDPNAD-dependent dehydrogenase / 0.760
5bqf NAPProbable hydroxyacid dehydrogenase protein / 0.753
4xcv NDPProbable hydroxyacid dehydrogenase protein / 0.750
3kb6 NADD-lactate dehydrogenase / 0.720
4nu5 NADPhosphonate dehydrogenase 1.20.1.1 0.720
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.716
3kbo NDPGlyoxylate/hydroxypyruvate reductase A / 0.714
4nu6 NADPhosphonate dehydrogenase 1.20.1.1 0.702
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.698
4e5p NADPhosphonate dehydrogenase 1.20.1.1 0.698
4e5m NAPPhosphonate dehydrogenase 1.20.1.1 0.694
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.684
4e5n NADPhosphonate dehydrogenase 1.20.1.1 0.676
4c4o NADSADH / 0.675
2dbq NAPGlyoxylate reductase 1.1.1.26 0.674
2o4c NADErythronate-4-phosphate dehydrogenase / 0.673
4k28 NADShikimate dehydrogenase family protein / 0.673
3jv7 NADSecondary alcohol dehydrogenase / 0.672
3wv7 ADPHmd co-occurring protein HcgE / 0.671
1dxy NADD-2-hydroxyisocaproate dehydrogenase 1.1.1 0.666
1psd NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.664
4j43 NADUncharacterized protein / 0.663
3phi NDPShikimate dehydrogenase (NADP(+)) / 0.662
2p9e NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.660
2dc1 NADProbable L-aspartate dehydrogenase / 0.659
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.658
4ebf NADPhosphonate dehydrogenase 1.20.1.1 0.658
4jk3 NADUncharacterized protein / 0.655
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.654
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.654
5doz NDPJamJ / 0.654
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.651