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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4xey 1N1 Tyrosine-protein kinase ABL1 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4xey 1N1Tyrosine-protein kinase ABL1 2.7.10.2 1.060
2gqg 1N1Tyrosine-protein kinase ABL1 2.7.10.2 0.947
2zva 1N1Tyrosine-protein kinase Lyn 2.7.10.2 0.906
4xli 1N1Abelson tyrosine-protein kinase 2 2.7.10.2 0.871
3qlg 1N1Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.869
3oct 1N1Tyrosine-protein kinase BTK 2.7.10.2 0.866
5bvw 1N1Epithelial discoidin domain-containing receptor 1 2.7.10.1 0.786
2hzi JINTyrosine-protein kinase ABL1 2.7.10.2 0.779
3lfa 1N1Mitogen-activated protein kinase 14 / 0.769
2zyb KSLTyrosine-protein kinase Lck 2.7.10.2 0.756
2g2h P16Tyrosine-protein kinase ABL1 2.7.10.2 0.750
4eh6 0ONMitogen-activated protein kinase 14 / 0.746
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4kip 1R9Mitogen-activated protein kinase 14 / 0.735
3itz P66Mitogen-activated protein kinase 14 / 0.711
3ocg OCGMitogen-activated protein kinase 14 / 0.694
3l8x N4DMitogen-activated protein kinase 14 / 0.685
3fsf FSSMitogen-activated protein kinase 14 / 0.672
1m52 P17Tyrosine-protein kinase ABL1 2.7.10.2 0.663
2zm4 KSMTyrosine-protein kinase Lck 2.7.10.2 0.663
4kin 1M8Mitogen-activated protein kinase 14 / 0.662
1qpe PP2Tyrosine-protein kinase Lck 2.7.10.2 0.660
4e5f 0N7Polymerase acidic protein / 0.660
3fkl FKLMitogen-activated protein kinase 14 / 0.658
4qms 1N1Serine/threonine-protein kinase 24 2.7.11.1 0.658
2uzt SS3cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
3mvm 39PMitogen-activated protein kinase 14 / 0.650