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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4wkq IRE Epidermal growth factor receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4wkq IREEpidermal growth factor receptor 2.7.10.1 1.099
2itz IREEpidermal growth factor receptor 2.7.10.1 0.911
4i22 IREEpidermal growth factor receptor 2.7.10.1 0.803
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4jq7 KJQEpidermal growth factor receptor 2.7.10.1 0.723
4bc6 XZNSerine/threonine-protein kinase 10 2.7.11.1 0.711
4jr3 KJREpidermal growth factor receptor 2.7.10.1 0.699
3ue4 DB8Tyrosine-protein kinase ABL1 2.7.10.2 0.690
4jrv KJVEpidermal growth factor receptor 2.7.10.1 0.687
2itp AEEEpidermal growth factor receptor 2.7.10.1 0.678
4i23 1C9Epidermal growth factor receptor 2.7.10.1 0.670
4jq8 KJ8Epidermal growth factor receptor 2.7.10.1 0.668
4mxo DB8Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.663
4e5f 0N7Polymerase acidic protein / 0.660
4fny I3KALK tyrosine kinase receptor 2.7.10.1 0.658
4g2f C07Ephrin type-A receptor 3 2.7.10.1 0.658
2vwu 7X1Ephrin type-B receptor 4 2.7.10.1 0.654
4mxx DB8Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.654
2r0u M54Serine/threonine-protein kinase Chk1 2.7.11.1 0.650