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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4uth FMN Xenobiotic reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4uth FMNXenobiotic reductase / 1.253
4utm FNRXenobiotic reductase / 1.250
5cpm FNRNADH:flavin oxidoreductase / 1.227
3l5l FMNXenobiotic reductase / 1.225
3l67 FMNXenobiotic reductase / 1.221
4utk FNRXenobiotic reductase / 1.207
3n14 FMNXenobiotic reductase / 1.170
2h8x FMNXenA / 1.159
4utl FNRXenobiotic reductase / 1.153
3n19 FNRXenobiotic reductase / 1.139
1z44 FMNNADPH dehydrogenase / 1.073
2gou FMNNADH:flavin oxidoreductase Sye1 / 1.063
2gqa FMNNADH:flavin oxidoreductase Sye1 / 1.057
1z48 FMNNADPH dehydrogenase / 1.029
3tjl FMNNADPH dehydrogenase / 0.993
1z41 FMNNADPH dehydrogenase / 0.992
3hf3 FMNChromate reductase / 0.988
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 0.978
4df2 FMNNADPH dehydrogenase / 0.972
3kru FMNNADH:flavin oxidoreductase/NADH oxidase / 0.967
2hsa FMN12-oxophytodienoate reductase 3 1.3.1.42 0.943
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 0.937
4b5n FMNNAD(P)H:flavin oxidoreductase Sye4 / 0.935
4m5p FMNNADPH dehydrogenase / 0.933
4h6k FMNNADPH dehydrogenase 1 1.6.99.1 0.925
4tmc FMNOld yellow enzyme / 0.922
4qnw FMNChanoclavine-I aldehyde reductase easA / 0.919
3gr8 FMNNADPH dehydrogenase / 0.909
3p8j FMNPentaerythritol tetranitrate reductase / 0.901
1bwl FMNNADPH dehydrogenase 1 1.6.99.1 0.895
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 0.895
4aws FMNNADH:flavin oxidoreductase Sye1 / 0.894
1q45 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.891
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 0.887
3f03 FMNPentaerythritol tetranitrate reductase / 0.886
3p84 FMNPentaerythritol tetranitrate reductase / 0.883
1gwj FMNMorphinone reductase / 0.881
2hs8 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.879
1vyr FMNPentaerythritol tetranitrate reductase / 0.875
2abb FMNPentaerythritol tetranitrate reductase / 0.866
1djq FMNTrimethylamine dehydrogenase 1.5.8.2 0.865
1vhn FMNtRNA-dihydrouridine synthase / 0.865
1jub FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.862
3p8i FMNPentaerythritol tetranitrate reductase / 0.861
2djl FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.859
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 0.859
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 0.858
2djx FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.858
2hs6 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.856
3p74 FMNPentaerythritol tetranitrate reductase / 0.856
4yco FMNtRNA-dihydrouridine(16) synthase / 0.855
2zfa FMNLactate oxidase / 0.854
4k7y FMNNADPH dehydrogenase 1 1.6.99.1 0.854
4awt FMNNADH:flavin oxidoreductase Sye1 / 0.853
1jue FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.851
2bsl FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.849
4e2d FMNDehydrogenase / 0.849
4qai FMNNADPH dehydrogenase / 0.846
1h50 FMNPentaerythritol tetranitrate reductase / 0.845
4ycp FMNtRNA-dihydrouridine(16) synthase / 0.845
1oya FMNNADPH dehydrogenase 1 1.6.99.1 0.844
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 0.837
4tmb FMNOld yellow enzyme / 0.837
2nli FMNLactate oxidase / 0.836
4rnv FMNNADPH dehydrogenase 1 1.6.99.1 0.834
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 0.834
4rnx FMNNADPH dehydrogenase 1 1.6.99.1 0.833
1h51 FMNPentaerythritol tetranitrate reductase / 0.831
3p67 FMNPentaerythritol tetranitrate reductase / 0.830
3p62 FMNPentaerythritol tetranitrate reductase / 0.829
3p82 FMNPentaerythritol tetranitrate reductase / 0.824
1dor FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.820
2zrv FNRIsopentenyl-diphosphate delta-isomerase / 0.820
3b05 FNRIsopentenyl-diphosphate delta-isomerase / 0.816
2j6x FMNLactate oxidase / 0.813
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 0.809
4bf9 FMNtRNA-dihydrouridine(16) synthase / 0.808
1h63 FMNPentaerythritol tetranitrate reductase / 0.802
1ofd FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.801
3b04 OOPIsopentenyl-diphosphate delta-isomerase / 0.801
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.800
3vkj FNRIsopentenyl-diphosphate delta-isomerase / 0.800
4jic FMNGTN Reductase / 0.799
3gka FMNN-ethylmaleimide reductase / 0.796
4a3u FMNNADH:flavin oxidoreductase/NADH oxidase / 0.792
4yl2 FMNLactate oxidase / 0.789
2q3r FMN12-oxophytodienoate reductase 1 1.3.1.42 0.774
3atz FMNProstaglandin F2a synthase / 0.772
3aty FMNProstaglandin F2a synthase / 0.769
1k02 FMNNADPH dehydrogenase 1 1.6.99.1 0.767
1llw FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.767
1kbj FMNCytochrome b2, mitochondrial 1.1.2.3 0.765
2z6i FMN2-nitropropane dioxygenase / 0.765
1ep3 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.758
3oix FMNDihydroorotate dehydrogenase / 0.758
4iql FMNEnoyl-(Acyl-carrier-protein) reductase II / 0.754
3c3n FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.753
4xq6 FMNDihydroorotate dehydrogenase (quinone) / 0.747
2zrz FNRIsopentenyl-diphosphate delta-isomerase / 0.746
1h7w FMNDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.745
1ofe FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.744
4yx6 FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.734
4cw5 FMNDfnA / 0.730
1fcb FMNCytochrome b2, mitochondrial 1.1.2.3 0.727
1szf FMNCytochrome b2, mitochondrial 1.1.2.3 0.725
4z9r FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.724
1kbi FMNCytochrome b2, mitochondrial 1.1.2.3 0.720
1ea0 FMNGlutamate synthase [NADPH] large chain 1.4.1.13 0.709
2b3d FADModulator of drug activity B / 0.707
3giy FMN(S)-mandelate dehydrogenase 1.1.99.31 0.703
2du2 FMNLactate oxidase / 0.700
3gye FMNDihydroorotate dehydrogenase (fumarate) / 0.696
4q4k FMNUncharacterized protein / 0.693
4n65 FMNFMN-dependent NADH-azoreductase 1 / 0.692
4ef8 FMNDihydroorotate dehydrogenase (fumarate) / 0.691
4ef9 FMNDihydroorotate dehydrogenase (fumarate) / 0.691
5ebu FMNLactate oxidase / 0.691
4zvn FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.688
2e77 FMNLactate oxidase / 0.687
4rje FNRLactate oxidase / 0.687
4wzh FMNDihydroorotate dehydrogenase (fumarate) / 0.687
1kbq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.685
2q3o FMN12-oxophytodienoate reductase 3 1.3.1.42 0.680
2zry FNRIsopentenyl-diphosphate delta-isomerase / 0.680
1qbg FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.675
2g86 UMPThymidylate synthase / 0.673
3bw3 FMNPutative 2-nitropropane dioxygenase / 0.671
4hnb FMNLOV protein / 0.670
1llz FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.669
1tj0 FADBifunctional protein PutA 1.5.5.2 0.664
2gjl FMNNitronate monooxygenase 1.13.12.16 0.664
2ohj FMNType A flavoprotein FprA 1 0.662
1dxq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.661
3bw2 FMNPutative 2-nitropropane dioxygenase / 0.661
4j8p FMNFlavodoxin / 0.660
1ep1 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.659
3g5m FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.659
4l82 FMNUncharacterized protein / 0.659
5a4k FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.659
1uum FMNDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.657
3mpi FADGlutaryl-CoA dehydrogenase 1.3.99.32 0.656
4qof FMNRibosyldihydronicotinamide dehydrogenase [quinone] / 0.656
2c12 FADNitroalkane oxidase 1.7.3.1 0.653
2zrx FMNIsopentenyl-diphosphate delta-isomerase / 0.653
4hj4 FMNLOV protein / 0.653
2vyx FMNDodecin / 0.650