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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4u97 STU Interleukin-1 receptor-associated kinase 4 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4u97 STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.959
1u59 STUTyrosine-protein kinase ZAP-70 2.7.10.2 0.843
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.832
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 0.822
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.808
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.805
4u9a STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.794
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.790
2gcd STUSerine/threonine-protein kinase TAO2 2.7.11.1 0.783
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.782
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.768
2yn8 STUEphrin type-B receptor 4 2.7.10.1 0.766
1qpd STUTyrosine-protein kinase Lck 2.7.10.2 0.762
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.747
4e5i 0N9Polymerase acidic protein / 0.744
1stc STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.742
3bkb STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.742
1nxk STUMAP kinase-activated protein kinase 2 2.7.11.1 0.741
2j0m 4STFocal adhesion kinase 1 2.7.10.2 0.741
1q3d STUGlycogen synthase kinase-3 beta 2.7.11.26 0.738
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.737
4qmy STUSerine/threonine-protein kinase 24 2.7.11.1 0.737
1yvj 4STTyrosine-protein kinase JAK3 2.7.10.2 0.734
3cbl STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.731
2hy8 1STSerine/threonine-protein kinase PAK 1 2.7.11.1 0.727
1qpj STUTyrosine-protein kinase Lck 2.7.10.2 0.720
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.720
5e8x STUTGF-beta receptor type-1 2.7.11.30 0.716
1oky STU3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.714
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.714
1byg STUTyrosine-protein kinase CSK / 0.709
4erw STUCyclin-dependent kinase 2 2.7.11.22 0.706
1nvs UCMSerine/threonine-protein kinase Chk1 2.7.11.1 0.705
4wsq KSAAP2-associated protein kinase 1 2.7.11.1 0.704
1snu STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.697
4kik KSAInhibitor of nuclear factor kappa-B kinase subunit beta 2.7.11.10 0.696
4fr4 STUSerine/threonine-protein kinase 32A 2.7.11.1 0.689
5e8y STUTGF-beta receptor type-2 2.7.11.30 0.689
4yzc STUSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.688
3a4o STUTyrosine-protein kinase Lyn 2.7.10.2 0.680
1xjd STUProtein kinase C theta type 2.7.11.13 0.679
3qzh X69Cyclin-dependent kinase 2 2.7.11.22 0.669
3f69 XDRSerine/threonine-protein kinase PknB 2.7.11.1 0.666
3ckx STUSerine/threonine-protein kinase 24 2.7.11.1 0.661
4e5f 0N7Polymerase acidic protein / 0.660
4gh2 HK0Serine/threonine-protein kinase Chk1 2.7.11.1 0.656
2gnh H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650