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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4tnq TTP Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4tnq TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.372
4tnx DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.200
4tnp DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.187
4to5 TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.182
4to0 DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.149
4qfx DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.051
4to4 DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.045
4to6 DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.042
4zwg DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.040
4tnz DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.028
4to3 DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.002
4qfy DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.953
4tny DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.898
4tnr DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.867
4bzc T8TDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.726
3m0e ATPTranscriptional regulator (NtrC family) / 0.686
2olr ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.684
4lrl TTPHD domain protein / 0.677
3rbm B73Farnesyl pyrophosphate synthase, putative / 0.674
4tnz TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.674
4mkf AP5Adenylate kinase / 0.673
2vp0 TTPDeoxynucleoside kinase / 0.672
4mit GTPRho-related protein racC / 0.672
2j0s ANPEukaryotic initiation factor 4A-III 3.6.4.13 0.671
4dxj 0M9Farnesyl pyrophosphate synthase / 0.671
3h5n ATPMccB protein / 0.667
4idn GNPAtlastin-1 3.6.5 0.666
4tlc AGSCircadian clock protein kinase KaiC 2.7.11.1 0.664
3tkl GTPRas-related protein Rab-1A / 0.663
1z2c GNPRho-related GTP-binding protein RhoC / 0.662
1h8h ATPATP synthase subunit alpha, mitochondrial / 0.661
1h8h ATPATP synthase subunit beta, mitochondrial 3.6.3.14 0.661
2w5a ADPSerine/threonine-protein kinase Nek2 2.7.11.1 0.661
4cei ANPATP-dependent helicase/deoxyribonuclease subunit B 3.1 0.661
2fah GDPPhosphoenolpyruvate carboxykinase [GTP], mitochondrial 4.1.1.32 0.660
3dt2 GTPPhosphoenolpyruvate carboxykinase, cytosolic [GTP] 4.1.1.32 0.660
3mhy ATPNitrogen regulatory protein P-II 1 / 0.657
1yzq GNPRas-related protein Rab-6A / 0.656
3wyf GTPGTP-binding nuclear protein / 0.656
1q3h ANPCystic fibrosis transmembrane conductance regulator / 0.655
1vg8 GNPRas-related protein Rab-7a / 0.654
2j9g ANPBiotin carboxylase 6.3.4.14 0.653
2r9v ATPATP synthase subunit alpha / 0.653
1dlj UGAUDP-glucose 6-dehydrogenase / 0.652
2py7 ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.652
4fj5 DTPDNA-directed DNA polymerase / 0.652
1os1 ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.650
2xka GSPCell division protein FtsZ / 0.650
3ahj TPPProbable phosphoketolase / 0.650