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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ros APR Malate dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ros APRMalate dehydrogenase / 0.973
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.892
1pzh NADLactate dehydrogenase / 0.886
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.877
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.868
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.865
1sow NADL-lactate dehydrogenase 1.1.1.27 0.853
1pzg A3DLactate dehydrogenase / 0.850
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.843
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.837
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.830
2a92 NAIL-lactate dehydrogenase / 0.816
1pzf A3DLactate dehydrogenase / 0.784
5a1t NAIL-lactate dehydrogenase / 0.775
2x0i NAIMalate dehydrogenase / 0.772
2aa3 AP0L-lactate dehydrogenase / 0.769
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.765
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.761
1ib6 NADMalate dehydrogenase / 0.756
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.755
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.754
1bdm NAXMalate dehydrogenase / 0.753
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.750
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.740
2dvm NAD439aa long hypothetical malate oxidoreductase (NAD) [malic enzyme] / 0.738
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.736
2hjr APRMalate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase / 0.731
1gv0 NADMalate dehydrogenase / 0.719
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.719
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.718
1c1d NAIPhenylalanine dehydrogenase / 0.717
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.711
3a4v NADNDP-sugar epimerase / 0.709
1ie3 NADMalate dehydrogenase / 0.707
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.703
2o4c NADErythronate-4-phosphate dehydrogenase / 0.701
1b8v NADMalate dehydrogenase / 0.699
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.698
3abi NADUncharacterized protein / 0.696
1uxk NADMalate dehydrogenase / 0.694
1y7t NDPMalate dehydrogenase / 0.692
4cr8 NADN-acylmannosamine 1-dehydrogenase 1.1.1.233 0.692
4k28 NADShikimate dehydrogenase family protein / 0.692
1yba NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.691
2p9e NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.691
1dxy NADD-2-hydroxyisocaproate dehydrogenase 1.1.1 0.690
4idg NADPutative UDP-glucose 4-epimerase / 0.690
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.690
1wze NADMalate dehydrogenase / 0.689
2pa3 NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.689
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.688
1zem NADXylitol dehydrogenase / 0.687
3adp NAILambda-crystallin 1.1.1.45 0.686
1bmd NADMalate dehydrogenase / 0.683
1f8f NADBenzyl alcohol dehydrogenase / 0.682
3ggp NADPrephenate dehydrogenase / 0.681
3gvh NADMalate dehydrogenase / 0.679
3gvi ADPMalate dehydrogenase / 0.678
1emd NADMalate dehydrogenase / 0.676
4i1i NADMalate dehydrogenase / 0.676
2p9g NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.674
2voj NADAlanine dehydrogenase 1.4.1.1 0.673
2p9c NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.672
4wlo NAIMalate dehydrogenase, mitochondrial 1.1.1.37 0.671
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.670
3h3f NAIL-lactate dehydrogenase A chain 1.1.1.27 0.670
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.670
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.670
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.670
2yy7 NADL-threonine dehydrogenase / 0.669
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.669
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.668
3ec7 NADInositol 2-dehydrogenase / 0.668
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.667
3uxy NADShort-chain dehydrogenase/reductase SDR / 0.666
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.664
2ztm NADD(-)-3-hydroxybutyrate dehydrogenase / 0.662
3rfx NADUronate dehydrogenase / 0.662
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.661
1q7g NHOHomoserine dehydrogenase 1.1.1.3 0.661
2dkn NAI3-alpha-hydroxysteroid dehydrogenase / 0.661
3ehe NADUDP-glucose 4-epimerase (GalE-1) / 0.661
1i36 NAPConserved protein / 0.660
3oet NADErythronate-4-phosphate dehydrogenase / 0.659
4b4o NDPEpimerase family protein SDR39U1 / 0.659
3ru9 NADUDP-N-acetylglucosamine 4-epimerase / 0.658
1bw9 NADPhenylalanine dehydrogenase / 0.657
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.657
2c29 NAPDihydroflavonol 4-reductase / 0.656
2g5c NADPrephenate dehydrogenase / 0.656
2nnl NAPDihydroflavonol 4-reductase 1.1.1.219 0.656
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.656
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.655
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.655
4o0l NDPNADPH-dependent 3-quinuclidinone reductase / 0.655
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.655
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.654
3icp NADNAD-dependent epimerase/dehydratase / 0.654
3q3c NADNAD-dependent L-serine dehydrogenase / 0.654
4yag NAIC alpha-dehydrogenase / 0.654
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.653
1ez4 NADL-lactate dehydrogenase 1.1.1.27 0.653
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.653
1pj2 NAINAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.653
4gll NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.653
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.653
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.653
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.653
1b3r NADAdenosylhomocysteinase 3.3.1.1 0.652
1i2b NADUDP-sulfoquinovose synthase, chloroplastic 3.13.1.1 0.652
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.652
3lu1 NADUDP-N-acetylglucosamine 4-epimerase / 0.652
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.652
3nt4 NAIInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.651
4pzd NAD3-Hydroxyacyl-CoA dehydrogenase / 0.651
4wji NAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase / 0.651
1wp4 NDP3-hydroxyisobutyrate dehydrogenase / 0.650
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.650
4id9 NADPutative UDP-glucose 4-epimerase / 0.650